Diphenhydramine is a first generation antihistamine. Capable of providing antispasmodic, local anesthetic and moderate ganglion-blocking effects. The main active ingredient is diphenhydramine.
An important distinguishing feature of the drug is its ability to create a calming effect, somewhat reminiscent of the effect of antipsychotic compounds. Diphenhydramine in certain doses has a very pronounced hypnotic effect. In addition, the medicine is known for its moderate antiemetic effects.
Compound
All forms of the medicine include the active ingredient clemastine in the form of clemastine hydrofumarate .
1 ml of solution contains 1 mg of active substance. Additional substances are: sodium citrate, ethanol, injection water, propylene glycol, sorbitol.
Tavegil tablets contain 1 mg of the active substance, as well as the following additional substances: povidone, lactose monohydrate, talc, magnesium stearate and corn starch.
Release form and composition of the drug Tavegil
Tavegil is available in the form of tablets, syrup for oral use and solution for injection into a muscle or vein.
White tablets in a blister of 5 or 10 pieces in a cardboard box with a detailed description attached. Each tablet of the medicine contains the active ingredient Clemastine 1 mg, as well as a number of excipients - lactose monohydrate, magnesium stearate, corn starch, povidone.
A special syrup form makes it easy to take for children over one year of age.
The injection solution is available in 5 ml transparent glass ampoules in plastic trays of 5 pieces in a cardboard package. Each ampoule of the drug contains 2 mg of the active component - Clemastine, the auxiliary components are ethanol, sorbitol, propylene glycol, water for injection, sodium citrate dihydrate.
Manufacturer: Novartis Consumer Health (Switzerland).
Pharmacodynamics and pharmacokinetics
The main active ingredient in the drug Tavegil is clemastine . In addition to the antiallergic effect, it has an anticholinergic, sedative effect, and reduces the permeability of the vascular wall. The drug does not have a hypnotic effect. Tavegil prevents contraction of smooth muscles and the development of vasodilation caused by the action of histamine. Clemastine reduces itching, has a local anesthetic effect, inhibits the formation of edema, exudation , and reduces the permeability of the capillary wall. During the experiment, it was found that Tavegil does not have teratogenic, mutagenic, or carcinogenic effects . When taking dosages 300 times higher than normal, fertility . After oral administration, the maximum effect is recorded after 6 hours and lasts up to 12 hours. Converted to metabolites in the liver, which are excreted 45-65 percent in the urine. Also, a small part is displayed unchanged.
Pharmacological properties
Pharmacodynamics
The active component of Tavegil, clemastine, is a blocker of H1-histamine receptors and belongs to ethanolamine derivatives. It is characterized by a strong antihistamine and antipruritic effect. The drug begins to act quickly, the duration of action reaches 12 hours. Clemastine prevents the development of vasodilation and smooth muscle contraction that histamine induces. Tavegil exhibits antiallergic and anticholinergic effects, reduces itching, slows down the formation of edema, inhibits exudation, and reduces the permeability of blood vessels and capillaries.
Pharmacokinetics
After oral administration of Tavegil, clemastine is almost 100% absorbed from the gastrointestinal tract (GIT). Its maximum plasma concentration is recorded 2–4 hours after administration.
The degree of binding to blood plasma proteins reaches 95%. The drug is excreted from the body in a biphasic manner, the corresponding half-lives being 3.6±0.9 and 37±16 hours. Clemastine is actively involved in hepatic metabolism processes. Excretion of metabolites occurs primarily through the kidneys (approximately 45–65%), and the active substance, unchanged, is found in urine only in trace concentrations. In nursing women, clemastine may pass into breast milk in small quantities.
Indications for use of Tavegil
What are the tablets for, and what are the solution and syrup used for?
The medicine is prescribed for allergic urticaria , hay fever, allergic rhinitis, eczema, pruritic dermatosis , contact dermatitis, drug allergies , allergies to insect bites. Indications for the use of Tavegil are also: hemorrhagic vasculitis , serum sickness, pseudoallergic reaction, anaphylactic shock, acute iridocyclitis .
Contraindications
Tavegil is contraindicated during pregnancy, intolerance to clemastine, and breastfeeding. The drug is not used in the treatment of MAO inhibitors, bronchial asthma, diseases of the lower respiratory tract, or in pediatrics. For pyloric stenosis , bladder neck obstruction, angle-closure glaucoma, prostatic hyperplasia, heart disease, thyrotoxicosis , arterial hypertension, Tavegil is used with caution. Children under one year of age are prescribed the drug in the form of injection solutions and syrup. The tablet form of the drug can be taken after reaching 6 years of age.
Analogs
- Diphenhydramine tablets - the Russian version, the price of this drug is from 131 rubles;
- Donormil, also in tablets - a French analogue, its price starts from 222 rubles;
- Suprastin tablets are a Hungarian analogue, price from 137 rubles.
In what forms is Tavegil produced:
- Injection;
- Syrup;
- Pills.
People usually face the question of which is better: Tavegil or Suprastin, let's figure it out.
Tavegil is a Russian drug, and Suprastin is brought from abroad. The active ingredients are different: Tavegil has clemastine, and Suprastin has chloropyramine, but both drugs are quite effective in saving the body from allergies. The advantage of Tavegil is that it does not have a sedative (calming) effect, which Suprastin cannot boast of. But it can be given to children up to one year old, unlike Tavegil. In any case, which drug to choose for yourself and your child is up to you, just consult your doctor first.
Side effects
Nervous system: tremors of the limbs, dizziness, increased drowsiness, fatigue, feeling tired, headaches, impaired coordination of movements, lethargy. In children, there is a stimulating effect of the drug on the nervous system, manifested by convulsions, euphoria , agitation, anxiety, neuritis , paresthesia , hysteria, and insomnia.
Sense organs: tinnitus, acute labyrinthitis , diplopia, disturbances in the functioning of the visual analyzer.
Digestive system: gastralgia , dyspeptic disorders, stool disorders, vomiting, loss of appetite, dry mouth.
Urinary system: difficulty urinating, frequent urge.
Respiratory system: nasal congestion, disturbances and difficulty breathing, pressure behind the sternum, difficulty in separating sputum, thickening of the secretion of the bronchial tree.
Cardiovascular system: extrasystole , rapid heartbeat, drop in blood pressure.
Hematopoietic organs: agranulocytosis, thrombocytopenia, hemolytic anemia . Possible development of bronchospasm , anaphylactic shock, shortness of breath, photosensitivity.
Overdose
An overdose of Tavegil can lead to both stimulating and suppressive effects on the central nervous system (CNS), with the former more often observed in pediatric patients. Signs of an anticholinergic effect are also sometimes observed: gastrointestinal disorders (nausea, vomiting, epigastric pain), dry mouth, flushing of the upper body, fixed dilation of the pupils.
If the patient does not have spontaneous vomiting, it must be induced artificially, but only if the patient’s consciousness is completely preserved. If 3 hours or more have passed since taking Tavegil, it is recommended to perform gastric lavage using activated charcoal and 0.9% sodium chloride solution. It is also possible to prescribe a saline laxative. If necessary, use symptomatic therapy.
Instructions for use of Tavegil (Method and dosage)
Tavegil tablets, instructions for use
The tablet form is taken orally twice a day at a dosage of 1 mg. The maximum permissible daily amount of Tavegil is 6 mg. Children: 0.5 mg twice a day. For children from 1 to 6 years old, the medicine is prescribed in the form of syrup, 1 teaspoon. It is not recommended to use the drug for children under 1 year of age.
Instructions for use of Tavegil in ampoules
Intravenous and intramuscular administration of the drug is carried out twice a day, 2 mg; children from 1 year to 12 years are given injections of 12.5 mcg/kg 2 times. To prevent allergies, 2 mg of clemastine is administered slowly intravenously once. The contents of the ampoule must be dissolved in 0.9% NaCl.
The medicine is not produced in the form of an ointment.
Tavegil: Application
Method of application of Tavegil and recommended doses
- Take the tablets orally, before meals, with water.
Adults and children over 12 years of age are prescribed 1 tablet. (1 mg) morning and evening. In exceptional cases, the daily dose can be increased to 6 tablets. Children 1 year old – 1/table in the morning and at night. - Tavegil injection solution is used intravenously or intramuscularly for adults, 2 mg. IV injections of Tavegil are carried out slowly, over min. For children, 25 mcg/kg/day is recommended for 2 administrations.
Adverse reactions of Tavegil
- headache, dizziness, drowsiness, sedation, tremor, increased fatigue, impaired coordination of movements; in children, there is an irritating effect on the central nervous system: increased irritability, agitation, insomnia, hysteria, convulsions;
- nausea, dyspepsia, dry mouth, vomiting, epigastric pain, constipation;
- increased or difficult urination;
- thickening of bronchial secretions, difficulty in releasing sputum, heavy breathing, a feeling of tightness in the chest area, nasal congestion;
- decreased blood pressure (in older people), extrasystole, palpitations;
- skin rash, urticaria;
- photo sensitization (rare);
- acute labyrinthitis, diplopia, disorder of clear visual perception, tinnitus;
- hemolytic anemia, agranulocytosis, thrombocytopenia.
Important instructions
While taking Tavegil, it is advisable to refrain from driving vehicles and from activities where there is a need for concentration.
Interaction with other LPs
Tavegil promotes the effects of drugs that depress the central nervous system (sedatives, hypnotics, tranquilizers), m-anticholinergics, and ethanol.
Tavegil or Suprastin?
The only difference between these drugs is the manufacturing companies.
Suprastin is a domestically produced drug, and Tavegil is produced abroad. Both drugs are successfully used for therapy for allergic rhinitis, allergic dermatosis, dermatitis, hay fever, conjunctivitis, and serum sickness. They cope well with allergic reactions caused by medications, as well as allergies that arise after insect bites.
Tavegil for children
This drug has long been recognized as one of the safest remedies against various types of allergic reactions.
The most important thing in this situation is that it is prescribed only to those children who have not been shown to have hypersensitivity to one of the constituent substances of this drug.
It is also worth remembering that Tavegil must be given to a child, strictly adhering to the recommended dosages. In no situation should you resort to self-medication. This drug can be absolutely safely used in the treatment of diseases in children such as: hay fever, drug rash, urticaria, eczema, contact dermatitis, often observed when using diapers. Tavegil often comes to the aid of parents in case of dermatoses, accompanied by severe itching, due to insect bites.
Analogs of the drug Tavegil
Experts consider the following drugs to be the most optimal options for replacing Tavegil, if necessary: Suprastin, Rivtagil, Clemastine-Eskom, Clemastine*, Clemastine.
The advisability of interchange is determined only by the attending physician when considering the individual predisposition of the patient.
special instructions
According to the annotation, the injection solution contains ethanol . During the treatment period, it is recommended to avoid drinking alcoholic beverages. Intra-arterial administration of the drug is not allowed. Elderly patients and children require careful monitoring during treatment. Tavegil is discontinued 72 hours before allergy tests in order to exclude the results of allergy prick tests . Tavegil affects driving vehicles and controlling complex mechanisms.
MNN: Clemastine.
Analogues of Tavegil
Level 4 ATC code matches:
Benadryl
Clemastine
Diphenhydramine
There are no direct analogues, but the drugs have a similar effect: Diphenhydramine , Suprastin , Pipolfen .
Tavegil price, where to buy
The price of Tavegil in 1 mg tablets is 120 rubles for 10 pieces, and 175 rubles for 20 pieces.
How much do allergy pills cost in Ukraine? The cost, for example, in Kharkov is 90 UAH for a package of 20 pieces.
The price of Tavegil in 2 ml ampoules is 185 rubles for 5 pieces.
It is extremely difficult to buy syrup in pharmacies.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Tavegil Tavegyl antiallergic drug, tablets, 1 mg, 20 pcs. Famar Italia SpA
218 rub. order - Tavegil Tavegyl antiallergic drug, tablets, 1 mg, 10 pcs. Famar Italy S.p.A.
166 RUR order
Pharmacy Dialogue
- Tavegil tablets 0.001g No. 10Novartis
RUB 154 order
- Tavegil (table 0.001g No. 10)Famar Italia Spa
RUB 173 order
- Tavegil (double) tablets 0.001g No. 20Famar Italia Spa
RUB 225 order
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Pharmacy24
- Tavegil 2 mg 2 ml No. 5 injection solution Takeda Austria GmbH, Austria
97 UAH.order - Tavegil 1 mg No. 20 tablets Famar Italy S.p.A. , Italy
79 UAH order
PaniPharmacy
- Tavegil ampoule Tavegil solution d/in. 1mg/ml amp. 2ml No. 5 Austria, Takeda Austria
104 UAH order
- Tavegil tablets Tavegil tablets. 1 mg No. 20 Italy, Famar Italia
92 UAH order
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Tavegil: Instructions
Release forms and composition
Tavegil tablets: 1 tablet (1 mg) contains clemastine;
auxiliary components: lactose monohydrate, povidone, corn starch, magnesium stearate, talc; 20 pcs. packaged. Tavegil solution for intramuscular and intravenous administration: 1 ampoule (2 ml) contains clemastine 2 mg; auxiliary components: ethanol, sorbitol, sodium citrate, propylene glycol, water for injection; 10 amp. in 2 packs.
Pharmacological characteristics
Tavegil is considered an antiallergic drug that blocks histamine H1 receptors.
It belongs to a number of antihistamines from the group of benzhydryl esters. Tavegil has a selective inhibitory effect on histamine H1 receptors, helping to reduce capillary permeability. It has antiallergic and antipruritic effects, characterized by rapid onset and significant duration.
When taken orally, the activity of this drug reaches its maximum level after an hour and lasts for an hour, in exceptional cases - up to 24 hours.
