Nowadays, allergies can easily be called one of the diseases of the century, because millions of people suffer from this disease. Allergy is a consequence of immune disorders, due to which the body becomes susceptible to various irritants, including seemingly harmless ones. Doctors say: you can get rid of allergies if you exclude the slightest contact with its cause (this or that irritant) and use an effective antihistamine. For example, the drug Erius or its analog Dezal.
Comparison of the effectiveness of Erius and Desal
Erius is more effective than Desal - this means that the ability of the medicinal substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Erius is more pronounced, then with Desal it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of therapeutic action in Erius and Dezal, as well as bioavailability - the amount of a medicinal substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Loratadine
second generation antihistamine . The main active ingredient is a substance with the same name. Available in two dosage forms: tablets and syrup.
Indications for use are:
- Allergic rhinitis and conjunctivitis.
- Dermatoses and dermatitis of various origins.
- Hay fever.
- Food and drug allergies.
Side effects when taken:
- Drowsiness, weakness, dizziness.
- Dry mouth, dyspepsia (nausea, vomiting).
- Tachycardia.
- Anxiety, nervous excitability (in children).
The main contraindications for use for treatment are:
- Children under 2 years of age.
- Pregnancy and lactation.
- Individual intolerance.
The average price in pharmacies is 15 rubles for a pack of tablets and 40 rubles for syrup.
Comparison of the safety of Erius and Desal
The safety of a drug includes many factors.
At the same time, Erius’s is higher than Desal’s. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Erius, as well as in Desal, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Erius has fewer risks when used than Dezal.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Erius and Desal.
What is the best way to treat allergies?
Most often, doctors prescribe a drug such as Erius. This drug is based on Desloratodine, available in syrup form, and has a sweet taste. Erius can be used by children from six months of age, but should not be used during pregnancy. It gives a good effect for urticaria and allergic cough.
You can often hear about the drug Allergostop; it is produced for both children and adults.
Like the first one, it contains a large amount of Desloratadine.
Suprastinex
In second place in popularity are drugs such as Suprastinex. It is available in tablets and drops. Tablets are for adults, and drops are for children from two years old. By attaching to histamine receptors, Levocetirizine, which is contained there, prevents their interaction with allergens. In record time, it eliminates problems such as swelling of the mucous membrane, redness and rashes on the skin.
Elimination takes from fifteen to sixty minutes. You need to take the product at least once a day.
Terfenadine
Not all products based on Levocetirizine can be given to children; before starting self-medication, it is important to consult with your local pediatrician. Terfenadine-based drugs are prescribed to people with heart problems; the fact is that these drugs do not have a cardiotoxic effect on blood vessels. One of these medications is Fexadin. It is available in the form of tablets, which are taken one per day. It is not recommended to increase the dose without the doctor's permission. Fexadine has side effects such as dizziness and drowsiness.
Diazolin
Diazolin is a well-known drug; many other medicines are made on its basis.
Diazolin does not have a sedative effect and does not cause drowsiness. That is why it is so often prescribed in clinics. Loratadine is often prescribed during seasonal allergies and has a good and quick effect.
Its dosage is no more than ten milligrams per day. For children, twice as much. An overdose leads to allergic reactions, the drug does not affect liver function and has an affordable price.
Comparison of habituation in Erius and Desal
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Erius is quite similar to the similar values in Desal. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, in Erius the meaning of the “syndrome” is quite small, however, the same as in Desal.
What is the best way to treat a child?
Infants and one-year-old children suffer from allergies more often than adults. This is mainly a food allergy associated with the child’s first feeding, or any allergens in the mother’s milk. This allergy manifests itself in different ways. This could be small rashes around the mouth and chin, or peeling and redness on the legs that itch terribly and the child cries for no reason.
In case of an allergy to construction dust, or the flowering of certain plants, a continuous cough and swelling of the mucous membrane appears. Not all drugs can be used to treat children, as they contain harmful substances that affect the health of the baby’s internal organs.
Claritin
A drug such as Claritin is quite often prescribed by doctors. Claritin is a syrup with a sweet taste; the excipient is Loratadine. It is an antisedative that does not cause drowsiness.
The dose of the drug should be minimal, half a teaspoon per day. Claritin is prescribed for: urticaria, redness, itching.
Erius
As mentioned above, children are prescribed a syrup called “Erius”; this drug is suitable for both children and adults. It does not penetrate the brain and does not cause a slowdown in reaction and attention.
Often children from one year of age with hives on the legs are prescribed “Eden”. It is not suitable for everyone, since in addition to Desloratadine, it contains sucrose.
It is sucrose that children are often allergic to; even in small quantities it can harm the child. If the baby tolerates sucrose normally, then he can take this syrup, half a spoon a day.
Allerzin
Allerzin, a drug based on Levocetirizine, has proven itself well. Children tolerate it well; it has contraindications for overdose, but no severe cases have been recorded. In order for the itching to go away, you need to take only six drops a day; this dose eliminates allergy symptoms for twenty-four hours.
Conclusion:
Fourth generation antiallergenic agents, suitable for both children and adults.
They are safer than their predecessors because they do not cause drowsiness or inhibition of reactions and do not affect the functioning of the heart. These drugs give a long-lasting effect, are available in tablets, drops, syrups in ampoules, based on:
- Doxylamine,
- Hifenadine,
- Klimastina,
- Cyproheptadine,
- Levoceterizine
Modern drugs have a quick effect. They remove any allergy symptoms within fifteen minutes. Their action lasts much longer than their predecessors. That is why doctors are increasingly prescribing these innovative drugs.
Comparison of side effects of Erius and Desal
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Erius's adverse event status is almost the same as Desal's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Erius are similar to Desal: how quickly the body recovers after taking it and whether it recovers at all.
Why are these products better than the previous ones?
Anti-allergenic agents 4 not only eliminate any manifestations of allergies, they have a long-lasting effect and quick action.
Unlike the first second and third generation drugs, the list of which is given above, they do not harm the nervous system and protect the cardiovascular system. They will also eliminate allergy symptoms such as:
- cough;
- itching;
- urticaria, small red rashes densely covering the skin;
- bouts of sneezing;
- swelling of the mucous membrane (including angioedema);
- redness.
First generation drugs
such as Promethazine cause drowsiness and can enhance the narcotic effect of other drugs. Affects the speed of reaction.
An integral part of such drugs is Deprazin.
Infegetramine causes spasm of the mucous membranes. Its components are Diphenhydramine and Alphadril. Its overdose causes headache, lack of urination, and constipation.
To second generation drugs
include: Zirtek, Fenprest, Fenistil - this is not the entire list of drugs. Zyrtec blocks H1 receptors. Its effect on the body lasts twenty-four hours. The drug acts on the speed of reaction. Side effects: weakness, headache, drowsiness.
Telafast, which is based on Fexofenodine, a third-generation drug. Unlike the two above drugs, it does not cause drowsiness, does not affect the speed of reaction, and does not interact with other drugs.
The duration of antihistamine action is twenty-four hours. This drug can be taken by people whose work involves driving a car, and other types of work, which are much easier to do without the effect of sleeping pills. The disadvantage of Telafast is its harmful effect on the liver; it is contraindicated for people with liver failure.
Lordestin - instructions for use (Method and dosage)
Lordestin tablets are intended for oral administration in their entirety. As the instructions for use of Lordestin recommend, this should be done every day at the same time, regardless of food intake, with liquid.
For adult patients and adolescents over 12 years of age, the average daily dosage is 5 mg or 1 tablet.
If patients suffer from chronic renal failure and liver failure, then the dosage regimen is adjusted. In such cases, an initial dose of 5 mg is prescribed every other day, regularly monitoring the patient's condition.
What do the drugs in question have in common?
In fact, Erius and Loratadine have the same effect on the body and are used for the same diseases. This is due to the fact that their main active ingredients are almost the same.
Loratadine in its pure form does not have an antihistamine effect; for this purpose, it is metabolized in the human liver into desloratadine, which has a therapeutic effect. Erius already initially contains this metabolite in its composition.
For this reason, simultaneous use of the drugs in question is strictly not recommended in order to avoid exceeding the concentration of desloratadine in the body and, as a result, overdose.
Compound
The drug contains the active ingredient: desloratadine hemisulfate.
Excipients: MCC, calcium hydrogen phosphate dihydrate, pregelatinized starch, colloidal silicon dioxide and magnesium stearate.
The composition of the film shell includes: Opadry AMB yellow 80W22099 or partially hydrolyzed polyvinyl alcohol, talc, titanium dioxide, lecithin, aluminum varnish based on quinoline yellow dye and indigo carmine dye, iron gum oxide yellow and xanthan.
Lordestin's analogs
Level 4 ATX code matches:
Dezal
Histaphene
Clarisens
Telfast
Erius
Claridol
Claritin
Loratadine
Fexofast
Peritol
Desloratadine
LauraHEXAL
Clarotadine
Rupafin
Ciel
Dramamine
Lomilan
Fenkarol
Kestin
Loratek
The main analogues of Lordestin are represented by the following drugs: Erius, Fenistil, Desloratadine, Tavegil, Canon, Desloratadine hemisulfate, Loratadine, Ezlor, Nalorius and others.
Lordestin or Erius - which is better?
One of Lordestin's main analogues is Erius . As clinical practice shows, it is these antiallergic drugs that are prescribed for seasonal relapses. Therefore, many patients are concerned about the question, which of these drugs is better?
However, according to experts, both drugs have almost the same effect. Before choosing a medicine, you should consult your doctor. It is possible to understand whether each drug really helps a particular patient only during the treatment process. In addition, people suffering from allergic reactions must adhere to other dietary and lifestyle rules so as not to provoke the development of reactions.
Differences between drugs
Erius belongs to the third generation of antihistamines, and this indicates greater safety compared to second generation anti-allergy drugs, which include Loratadine. Its undoubted advantage is that it comes in an already active form, without the need for the formation of metabolites in the liver.
In practice, this means that the effect of Erius occurs much faster, literally within half an hour after administration. This is especially true for stopping allergic reactions that occur suddenly. However, its antihistamine effect is relatively short. At the same time, Loratadine has some prolonged action due to the presence of the metabolic phase of the active component in the liver.
The effectiveness of the medications under consideration is largely similar, and the severity of their therapeutic effect depends on the individual characteristics of the body.
Erius practically does not take part in metabolic processes in the body, so the severity of side effects is much lower, and the frequency of their occurrence is comparable to the placebo effect. For the same reason, its use in pediatric practice is acceptable with virtually no restrictions. The only exception is the age of the child under six months and this is due to the lack of clinical studies. Loratadine is not used to treat children under 2 years of age, and under 12 years of age it should be used with caution. And although it practically does not cause serious side effects, the frequency of occurrence of the existing ones is quite high.
The drugs under consideration differ significantly in terms of price. Erius costs much more. This is explained mainly by its foreign origin.
Erius
Erius is a third-generation antihistamine, the main active ingredient of which is desloratadine , which is a metabolite of loratadine. It is available in two dosage forms: tablets and syrup.
It is used mainly for the following allergic reactions, such as:
- Various forms of dermatitis.
- Hives.
- Neurodermatitis.
- Food dermatoses.
- Hay fever.
- Allergic rhinitis and conjunctivitis.
Taking the medicine may cause the following side effects:
- Dizziness, weakness.
- Dry mouth.
- Tachycardia.
- Dyspeptic phenomena.
With an overdose of the drug, the severity of side effects increases.
Contraindications for use are: pregnancy and lactation, age under 6 months, individual intolerance to the components of the drug.
The average price is 620 rubles, regardless of the form of release.
New generation antihistamines: what to choose for an allergy sufferer?
Why are allergy medications divided into generations? What side effects do they give? Let's figure it out together with Medical Note.
Allergy medications: a brief history
In 1936, the first drugs were synthesized that could block H-1-histamine receptors. Experiments have shown that after taking these medications, histamine in the human body could no longer bind to these receptors, and therefore an allergic reaction did not develop.
The first anti-allergy drugs were antegran and pyrilamine. It would seem, what could be more beautiful? Problem solved. But further experiments showed that everything turned out to be much more complicated. It turned out that the coordinated functioning of the whole organism depends on histamine.
Why do we need histamine, and what does allergies have to do with it?
When exposed to histamine, gastric juice is released, smooth muscles contract, and blood vessels dilate. It is histamine that is responsible for how long you sleep and what time you wake up, controls the consumption of water and food, the body’s thermoregulation and its convulsive activity. Even sexual desire is an action, including histamine.
And, naturally, histamine is involved in the body’s controlled immune response to an irritant: runny nose, lacrimation, itching, sneezing, bronchospasm - all this is its work.
In the human body there are four types of histamine receptors, which are located in different tissues and organs:
- H1 - type 1 receptors - are located in the brain, intestinal smooth muscles, and blood vessels.
- H2 - receptors of the second type - in the tissues of the heart, gastric mucosa, smooth muscles, cartilage tissue.
- H3 - receptors of the third type - are located in the central nervous system.
- H4 receptors of the fourth type - in the bone marrow, intestinal tissues, leukocytes, spleen, thymus.
Its effect and further reaction depend on which receptor histamine binds to - from a simple sneeze and runny nose to instant Quincke's edema.
Therefore, to solve different problems of blocking certain receptors, different medications are needed: H1-, H2-, H3-, H4-blockers.
What are new generation antihistamines
When using the phrase “new generation antihistamines,” the patient should understand that these are H1 blockers that relieve allergies. It is H1 blockers that are sold in different forms and under different names in pharmacies.
H2 blockers are not divided into generations at all. H3 blockers are substances that are still being tested, while H4 blockers are still being developed in medical laboratories.
Allergy medications: counting generations
To date, there are only two generations of H1 blockers.
First generation
: diphenhydramine, chloropyramine (suprastin), pipolfen, ketotifen, diazolin, clemastine (tavegil), fenistil and others. These drugs, in addition to blocking H-1-histamine receptors, have the unpleasant property of being able to overcome the barrier between the blood and the brain.
Because of this, a lot of side effects appear: from absent-mindedness and decreased reaction speed to impaired coordination of movements and deterioration in the perception of information.
In addition, first-generation drugs have a bad effect on the cardiovascular system, digestive tract, and vision. In addition, all first-generation drugs have a short-term effect. The patient must take them several times a day, which only intensifies the side effects.
In general, the European Consortium for the Study of Allergy and Asthma (Global Allergy and Asthma European Network), after a long analysis of the risks of these drugs in 2010, recommended banning the over-the-counter sale of these drugs.
Second generation
: acrivastine, cetirizine, azelastine, olopatadine, loratadine, ketotifen, rupatadine, mizolastine, ebastine, bilastine, bepotastine, terfenadine, hifenadine, levocabastine, astemizole.
These drugs selectively block H-1-histamine receptors without interacting with other receptors. Second-generation drugs do not penetrate the blood-brain barrier and do not cause addiction or sedation. Taking the drug is limited to one tablet per day.
Unfortunately, second-generation drugs have a bad effect on the heart. For astemizole and terfenadine, this effect was so pronounced that the sale of this drug is prohibited in many countries.
Third generation drugs: legend or reality
Work to improve second-generation allergy drugs is ongoing. Scientists are receiving increasingly high-quality second-generation drugs, which some pharmacists even call «
third generation drugs
»
.
According to manufacturers, these substances have become more effective and do not cause serious side effects, like their predecessors. Let us name these substances and the trade names under which they are sold:
- levocetirizine (“Xyzal”, “Glencet”, “Suprastinex”, “Cesera”, “Elcet”, “Zodak Express”)
- desloratadine (Dezal, Loratek, Lordestin, Erius, Neoclaritin)
- fexofenadine (“Allegra”, “Telfast”, “Fexofast”, “Fexadin”, “Fexofen”)
However, the British Society of Allergists and Immunologists in 2003 refused to recognize these drugs as third-generation drugs.
According to the opinion of 17 experts from the UK, Italy, Canada, Japan, and the USA, real third-generation drugs are distinguished by:
- No cardiotoxicity;
- No interaction with other drugs;
- No effect on the central nervous system.
None of the improved second-generation drugs meet these stringent standards.
Second generation drugs: advantages and disadvantages
Allergies are not called “the plague of the 21st century” for nothing. A reaction to a product, pollen, or chemical can occur at any time, regardless of gender, age or race.
The “easiest” thing is with a reaction to a certain type of food - just give up the product, and an allergic reaction will not occur. Those whose bodies react to pollen or dust need daily assistance with medications.
A doctor* should choose a drug based on tests.
Levocetirizine
It begins to act an hour after administration and works for at least 24 hours.
Common side effects: drowsiness, headache, dizziness, dry mouth, fatigue, weakness, nasopharyngitis, pharyngitis, abdominal pain, nausea, fever.
Not for pregnant women, nursing mothers, children under 6 months (both drops and tablets), children under 6 years of age (tablets, drops are already allowed), people with hypersensitivity to levocetirizine, cetirizine, hydroxyzine or other components of the drug, end-stage renal failure, etc. who are undergoing hemodialysis.
It is not recommended to combine the medicine with alcohol and other depressants.
Desloratadine
Begins to act 2 hours after administration, works for 24 hours.
Common side effects: headache, dry mouth, fatigue, upset stomach, drowsiness, dizziness, muscle pain, dysmenorrhea.
Not for pregnant women, nursing mothers, children under 6 months (both syrup and tablets), children under 12 years old for tablets (syrup is okay), people with hypersensitivity to desloratadine, loratadine or other components of the drug.
Fexofenadine
Begins to act 2 hours after administration, works for 24 hours.
Common side effects: headache, dizziness, drowsiness, diarrhea, nausea, muscle pain, cough.
Not for pregnant women, nursing mothers, children under 12 years of age, or people with hypersensitivity to one of the components of the drug.
* Attention! The article does not list all the side effects of antihistamines! Before using any of the drugs, be sure to read the instructions or consult your doctor.
Antihistamines: why you can’t do without them
As we see, today a “universal soldier” has not yet been created to combat allergies. But even if you compare first-generation drugs and those that can be called “2.0+”, a noticeable difference is visible.
Despite all the difficulties, people with allergies should not skip taking antihistamines. If left untreated, allergies can eventually develop into asthma. To remember to take your medication on time, we recommend installing the Medical Note app on your phone.
The application has a convenient medical calendar that will promptly remind you to take your medication. The correct timing of taking medications will save you from the negative effects of a histamine reaction that occurs at the most inopportune moment.
Source: https://zen.yandex.ru/media/id/59c4ede73c50f71d116106cb/5bed84d733501200a9885bfb
Lordestin price, where to buy
The price of Lordestin in pharmacies in Russian regions is practically the same. Moreover, this drug can be bought at almost any pharmacy. The price of 10 tablets of Lordestin varies between 220-330 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Lordestin tablets p.p.o.
5 mg 10 pcs. Gedeon Richter-RUS ZAO 346 rub. order - Lordestin tablets p.p.o. 5 mg 30 pcs. Gedeon Richter-RUS ZAO
RUR 775 order
- Lordestin syrup 0.5 mg/ml 60 ml Gedeon Richter Romania A.O.
RUB 198 order
Pharmacy Dialogue
- Lordestin tablets 5 mg No. 10Gedeon-Richter
RUR 366 order
- Lordestin tablets 5 mg No. 30 Gedeon-Richter
RUR 788 order
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Which drug is better, Erius or Loratadine?
The range of antihistamines on pharmacy shelves is very wide. Without a doctor, it is almost impossible to figure out which medicine is better, more effective and safer.
Some of the most recognizable frequently purchased anti-allergy drugs are Erius and Loratadine. They are almost identical in principle of therapeutic action and have active substances with a similar name.
However, in some aspects these drugs differ significantly from each other, and therefore may be recommended for different categories of patients.
