"Fexadin": instructions for use

Author of the article

Mikhail Ivanovich Zlotonosov

Candidate of Medical Sciences Sci. Expert in the field of drugs.

Articles written

235

Allergies are one of the most common diseases, and its danger should not be underestimated. Allergies are characterized by a whole range of unpleasant symptoms: sneezing, nasal discharge, itching, swelling, skin rashes. The drug Fexadin will effectively help relieve all these manifestations.

What is Fexadin

Allergy tablets Fexadin or Fexadin are third-generation antihistamine allergy medications. The drug is not a hormonal or antibiotic drug. It is a generic version of the drug Telfast (Allegra) - it contains the same active substance, but has a lower cost due to the fact that the raw materials may not be so well purified from impurities. The drug is produced by the Indian pharmaceutical company Ranbaxy, and is effective within an hour for 2-12 hours.

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pharmachologic effect

The active component of Fexadine is fexofenadine, whose mechanism of action is associated with blocking H1-histamine receptors. The active substance belongs to the active metabolites of terfenadine, therefore it stabilizes the mast cell membrane and reduces the amount of released biologically active components, histamine. An hour after taking the tablets, an antiallergic effect develops in the body, which reaches its maximum after six hours and lasts up to a day.

Doctors note that patients receiving fexofenadine do not develop common side effects of other antihistamines - constipation, dry mouth, high cardiotoxicity, visual impairment, weight gain. For older people, with pathologies of the kidneys and liver, no dose adjustment of the drug is required. The medication does not enhance the effects of alcohol, alcohol-containing drinks and drugs that depress the nervous system.

The effect obtained when taking 10-130 mg of the drug is considered dose-dependent. Fexofenadine in the form of hydrochloride after oral administration is absorbed from the gastrointestinal tract (GIT), binds to plasma proteins by 6-70% (with albumin, alpha1-glycoprotein), does not penetrate the blood-brain barrier, 5% of the dose is partially metabolized. The elimination of the substance is biphasic, the elimination period is 22-20 hours, the elimination time increases with renal failure and during hemodialysis. The drug is excreted in bile and urine.

Pharmacological action and release form

Every person’s body contains a substance called histamine; in healthy people, this component “sleeps” in mast cells. When these cells encounter an irritant, they release histamine, which in turn provokes a number of symptoms, which are classified in medicine as allergies. Fexadin 180 blocks the release of histamine and has an antiallergic effect on the body. It also affects the activity of already released histamine and stabilizes the condition of a person who is faced with an irritating factor. The effect of using the medication, unlike other antihistamines, is observed within an hour after administration, and, as a rule, lasts throughout the day. Fexadin 120 is excreted in urine and feces after 48 hours.

The release form of the drug is convex-shaped tablets with a film coating. There are two types of tablets: 120 mg of active substance and 180 mg. Produced in cellular packages of 10 pieces in cardboard boxes of 5 blisters.

Compound

Depending on the form of release of the drug and the concentration of the active substance, the composition of the tablets differs:

Release form

The main active ingredient is fexofenadine hydrochloride 120 mg.

Auxiliary components: starch, povidone, silicon dioxide, magnesium stearate, purified water.

Fexadin is available in film-coated tablets. The shell of each tablet consists of titanium dioxide, red iron oxide, macrogol, food coloring.

10 tablets in a blister pack made of aluminum foil coated with vinyl chloride polymer film;

1 or 2 blister packs with instructions for use in a cardboard box.

1 film-coated tablet

contains active ingredient: fexofenadine hydrochloride

For tablets 120 mg - auxiliary ingredients: croscarmellose sodium - 20.00 mg, microcrystalline cellulose - 177.42 mg, gelatinized starch - 58.00 mg, colloidal silicon dioxide - 14.00 mg, povidone - 6.0 mg, magnesium stearate - 4.00 mg, purified water* - up to 400.00 mg.

Film coating: opadry pink dye (OY-54957) - 15.60 mg: (hypromellose, titanium dioxide, macrogol-400, red iron oxide dye (CI No. 77491), purified water*.

Printing ink: opacode SI-17823 black - qs: glazed shellac-45% (20% esterified) in ethanol, black iron oxide dye, N-butyl alcohol, propylene glycol, isopropanol, ammonium hydroxide 28%.

(*-evaporates during the production process).

For tablets 180 mg - auxiliary ingredients: croscarmellose sodium - 30.00 mg, microcrystalline cellulose - 266.13 mg, gelatinized starch - 87.00 mg, colloidal silicon dioxide - 21.00 mg, povidone - 9.0 mg, magnesium stearate - 6.00 mg, purified water* - up to 600.00 mg.

Film coating: opadry pink dye (OY-54957) - 23.40 mg: (hypromellose, titanium dioxide, macrogol-400, red iron oxide dye (CI No. 77491), purified water*.

glazed shellac-45% (20% esterified) in ethanol, black iron oxide dye, N-butyl alcohol, propylene glycol, isopropanol, ammonium hydroxide 28%.

(*-evaporates during the production process).

Indications for use

Fexadin 180 mg is intended for the treatment of chronic idiopathic urticaria, and a medicine with a concentration of 120 mg is intended for the treatment of seasonal hay fever and allergic rhinitis. General indications for use of the drug:

• treatment of chronic or seasonal allergies, hay fever, accompanied by sneezing, itching, coughing, redness and swelling of the mucous membranes, rhinitis, itching and urticaria;
• allergic cough;
• allergy to sunlight, pityriasis rosea;
• exudative or ordinary psoriasis (to reduce inflammation, erythema, itching, peeling).

Analogues of the drug

Fexadin analogues are drugs from the same pharmacological group that have the same or similar composition. The most expensive similar product is the drug Allegra (made in France). Medicines have the same release form and active ingredient in the composition. Cost of the drug Allegra: 10 tablets 120 mg - 664 rubles, 10 tablets 180 mg - 994 rubles.

A cheap analogue of Fexadin is Fexofast tablets. The cost of a package of 10 pieces of 120 mg is 280 rubles. The drugs have similar composition, side effects, and release form. Reviews about this medicine are also positive.

Instructions for use

The drug Fexadin is taken at any time of the day in a dosage prescribed by an allergist or therapist. Eating slows down the effect of the medication, so it is advisable to take the tablets before meals. The dosage differs depending on the type of disease:

The tablets are prescribed to adolescents and adults over the age of 12 and are available without a doctor’s prescription. The medicine should be stored in a dry place at a temperature not exceeding 25 degrees for three years. Unlike some other antihistamines, Fexadin does not affect concentration, the speed of psychomotor reactions, or performance function, therefore it can be used when driving vehicles and operating complex mechanisms, but after checking the individual reaction.

Directions for use and doses

Instructions for the use of Taktivin injections and analogues

Only a qualified specialist can tell you why and how to take Fexadin. In most cases, a single dose of 120 mg of the drug per day (1 tablet) is prescribed. If there is severe swelling of the mucous membranes or a relapse of the chronic form of the disease, a single dose of 180 mg tablets is prescribed. For patients aged 6 to 12 years, the dosage is 60 mg of the active ingredient, once a day (half a tablet). The same dosage is prescribed to people of retirement age (after 55 years). It is important to note that if the effect is not observed within 24 hours, then the use of the medicine is stopped and a new treatment tactic is selected. Take the tablets with water only. Coffee, juices and sweet carbonated waters can affect the duration of absorption of the active substance in tablets.

The duration of treatment with Fexadin is selected by the doctor depending on the complexity of the situation and the nature of the symptoms. It is prohibited to adjust the dosage at your discretion or stop taking the medication ahead of time.

The effect of the medication during pregnancy and breastfeeding has not been fully studied, so doctors try to avoid prescribing this drug during allergies. The use of Fexofenadine is justified if the antihistamine effect of the medication is higher than the risk for the child to be inside the womb.

Use for children

To date, there is no reliable information about the safety and effectiveness of Fexadin in children under six years of age. Doctors prescribe the drug to adolescents from 12 years of age. The dosage depends on the type of disease: for allergic rhinitis and hay fever, the medicine can be prescribed to children 6-12 years old, but at a dose of 60 mg/day. If the drug does not show an effect within 24 hours, then you need to consult a doctor for treatment adjustment. The duration of taking the medication is 7-10 days, the medicine does not have a cumulative effect.

Fexofenadine Akriquin reviews

– seasonal allergic rhinitis (to reduce symptoms) – tablets, 120 mg;

– chronic idiopathic urticaria (to reduce symptoms) – tablets, 180 mg.

Dosage form

film-coated tablets

Can the tablet be chewed, crushed or broken?

What if there are many components in it? What if it is covered with a shell? Read more.

Contraindications

– hypersensitivity to any of the components of the drug;

– children's age (up to 12 years).

The drug should be used with caution in patients with chronic renal and liver failure, as well as in elderly patients (lack of clinical experience in this category of patients); in patients with cardiovascular diseases, including a history (antihistamines can cause palpitations and tachycardia).

How to use: dosage and course of treatment

Intended for oral administration.

The recommended dose for seasonal allergic rhinitis for adults and children 12 years of age and older is 120 mg once daily.

The recommended dose for chronic urticaria for adults and children 12 years of age and older is 180 mg once daily.

pharmachologic effect

Fexofenadine, which is part of the drug, is an antihistamine with selective antagonistic activity to H1 receptors without anticholinergic and alpha1-adrenergic receptor blocking effects; fexofenadine also does not have sedative effects or other effects on the central nervous system.

The antihistamine effect of the drug appears after 1 hour, reaching a maximum after 6 hours, and lasts for 24 hours. After 28 days of use, no addiction was observed.

Side effects

Rarely: feeling tired, insomnia, nervousness, sleep disturbance.

In some cases: skin rash, urticaria, itching, other hypersensitivity reactions: angioedema, shortness of breath.

In case of overdose, dizziness, drowsiness and dry mouth may occur. In this case, standard measures are recommended to remove unabsorbed drug from the gastrointestinal tract. Symptomatic and supportive therapy is recommended. Hemodialysis is ineffective.

special instructions

The recommended time interval between taking the drug and antacids containing aluminum or magnesium hydroxide should be at least 2 hours.

When taking the drug, it is possible to perform work that requires a high concentration of attention and speed of psychomotor reactions, with the exception of patients who have a non-standard reaction. It is therefore recommended to check your individual response to fexofenadine before engaging in such activities.

Interaction

When fexofenadine hydrochloride is used together with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases by 2-3 times. There is no significant effect on prolongation of the QT interval.

Taking antacids containing aluminum or magnesium 15 minutes before taking the drug leads to a decrease in the bioavailability of fexofenadine.

Storage conditions

In a dry place, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the package.

Questions, answers, reviews on the drug Fexofenadine-Akrikhin

The information provided is intended for medical and pharmaceutical professionals. The most accurate information about the drug is contained in the instructions supplied with the packaging by the manufacturer. No information posted on this or any other page of our website can serve as a substitute for personal contact with a specialist.

Drugs produced on the basis of fexofenadine hydrochloride are effective drugs in the fight against allergies in adults and children. The medication has a minimum of contraindications and is excellent for long-term therapy, required, for example, in the treatment of urticaria.

Fexofenadine. Description of the medicine

The active ingredient is fexofenadine hydrochloride in a volume of 120 mg per tablet.

The active substances of Fexofenadine do not penetrate the meninges, and therefore do not cause side effects typical of antihistamines in the form of drowsiness and lethargy. The effect of the drug begins within an hour after administration, the maximum concentration of the active substance is reached after six hours.

Fexofenadine, produced in two release forms, is an antihistamine drug that blocks the functioning of H1 receptors, which are responsible for the release of histamine from organs and the development of an allergic reaction against this background. Effectiveness continues for 24 hours.

After oral administration, Fexofenadine undergoes rapid absorption from the gastrointestinal tract with penetration into the systemic circulation; more than 65% of the active substance is bound to plasma proteins. The drug is completely eliminated from the body after completion of treatment in 13-15 hours.

Only about five percent of the original dose is metabolized, excretion is carried out through bile (more than 80%) and through the genitourinary system (12%).

Fexofenadine. Indications for use

Fexofenadine is recommended for use in allergic rhinitis and chronic urticaria. An individual dosage is selected for each type of disease.

Fexofenadine. Instructions for use

Due to the special properties of Fexofenadine hydrochloride, it is advisable to take the drug before meals, waiting a half-hour interval after drinking the tablet.

For patients suffering from allergic conjunctivitis and rhinitis, a dose of 120 mg is prescribed once a day.

Source: https://za-dolgoletie.ru/info/feksofenadin-akrihin-otzyvy/

Side effects

If you take higher doses of the drug, the severity of side effects increases. Negative reactions of using Fexadin tablets include:

• fatigue, fatigue;
• dyspeptic disorders (nausea, vomiting, stomach pain, diarrhea, constipation);
• dysmenorrhea;
• hypersensitivity reactions (shortness of breath, angioedema, skin rash, urticaria, itching of the skin);
• insomnia, sleep disturbances, nervousness;
• dizziness, increased drowsiness, headache;
• pain in the heart, chest, tachycardia;
• photosensitivity (increased sensitivity of the skin to sunlight);
• anaphylactic reactions (swelling of the throat, difficulty breathing);
• disruption of taste buds.

Drug interactions

There are negative reviews from patients who simultaneously took Fexadin and other medications. Possible negative and dangerous reactions:

1. The combination of the drug with ketoconazole or erythromycin leads to an increase in the concentration of fexofenadine by 2-3 times. This occurs due to increased absorption in the digestive tract, reduced excretion of bile, a significant decrease in the production of gastric secretions, and effects on the intestines.
2. Antacids based on aluminum or magnesium ions reduce the bioavailability of fexofenadine, so at least two hours should pass between doses of antacids.
3. Doctors did not note any clinically significant interaction between Fexadine and Omeprazole.
4. It was found that the drug does not interact with drugs whose metabolism occurs in the hepatic system.
5. It is not recommended to combine the medication with alcohol and alcohol-containing drinks or medications, but Fexadin does not enhance the negative effect of ethanol on the central nervous system.

Pregnancy

Take pills

Contraindicated during pregnancy.

Interaction with other drugs: When Fexadine is used together with erythromycin or ketoconazole, the plasma concentration of Fexofenadine increases by 2-3 times.

There is no significant effect on increasing the QT interval. Taking aluminum or magnesium-containing antacids 15 minutes before taking fexofenadine leads to a decrease in the bioavailability of the latter (the time interval between their administration should be at least 2 hours). Does not interact with omeprazole.

Analogs

The original drug analogue of Fexadin is Telfast (Allegra), available in 120, 180 mg and 30 mg versions for children. Other drug substitutes include:

• Fexofast is a direct analogue of a drug based on fexofenadine and is an original medicine;
• Allerfex is a Russian antihistamine against urticaria and hay fever with the same active substance, but is rarely found on the market;
• Gifast is a drug based on fexofenadine hydrochloride, available in concentrations of 120 and 180 mg;
• Dinox - tablets based on fexofenadine;
• Fexofenadine is the most affordable analogue, based on the active component of the same name;
• Bexist-Sanovel is a histamine receptor blocker, containing the same active substance as the drug in question;
• Rapido - capsules against allergic rhinitis, do not have a sedative effect;
• Telfadine - tablets based on fexofenadine.

Drug interactions and compatibility with alcohol

It is not recommended to carry out simultaneous treatment with Fexadin, Ketoconazole and Erythromycin, since the latter increase the concentration of the drug in plasma. Because of this, the outflow of bile worsens, which negatively affects the functioning of the entire body. Antacids can be taken no earlier than 2 hours after Fexadin. The medicine does not interact with Omeprazole and does not reduce the effectiveness of oral contraceptives.

Compatibility with alcohol: Fexadin has no effect on the central nervous system, but it is better not to combine treatment with alcohol consumption. No negative effect of the drug on concentration has been established, so treatment with Fexadin can be carried out without removing a person from driving a car and other mechanisms. But to be sure, it is better to check a person’s reaction individually.

Price

Tablets can be ordered through a catalog, bought in an online store or pharmacy at a cost that is influenced by the release form, the concentration of the active substance and the level of trade markup. Approximate prices for the drug and its analogues in Moscow:

FEXADIN

– fexofenadine hydrochloride (fexofenadine)

Composition and release form of the drug

10 pieces. – blister contour packages (1) – cardboard packs. 10 pieces. – blister contour packages (2) – cardboard packs.

Pharmacokinetics

After oral administration, it is quickly absorbed from the gastrointestinal tract, Cmax is determined after 1-3 hours. The average Cmax after taking 180 mg is approximately 494 ng/ml, and after taking 120 mg – 427 ng/ml.

Plasma protein binding – 60-70%. T1/2 after repeated doses – 11-15 hours. Excreted in breast milk. 5% of the dose undergoes partial extrahepatic metabolism.

It is excreted mainly in bile (80%), 10% is excreted unchanged by the kidneys.

Indications

Elimination of symptoms associated with seasonal allergic rhinitis, symptomatic treatment of chronic urticaria.

Dosage

For adults and children over 12 years of age, the daily dose is 120-180 mg (1 time/day).

Maybe:

headache, drowsiness, dizziness, fatigue, nausea, lethargy, increased fatigue.

Drug interactions

Fexofenadine is not biotransformed in the liver and therefore does not interact with other drugs undergoing hepatic metabolism.

It has been shown that with simultaneous use of fexofenadine with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases 2-3 times, which is apparently associated with an increase in absorption from the gastrointestinal tract and a reduction in either bile excretion or gastrointestinal secretion. However, no changes in the QT interval were observed.

When taking antacids containing aluminum or magnesium 15 minutes before taking fexofenadine, a decrease in its bioavailability was observed, most likely due to binding in the gastrointestinal tract. The recommended time interval between taking fexofenadine and antacids containing aluminum or magnesium hydroxide is 2 hours.

Does not interact with omeprazole or drugs metabolized in the liver.

Pregnancy and lactation

Fexofenadine is contraindicated for use during pregnancy and lactation (breastfeeding).

Fexofenadine passes into breast milk. If it is necessary to use fexofenadine during lactation, the issue of stopping breastfeeding should be decided.

Use in childhood

The use of the drug in children under 6 years of age is not recommended.

For impaired renal function

Use with caution in patients with renal failure.

For liver dysfunction

Use with caution in patients with liver failure.

Use in old age

Use with caution in elderly patients.

The description of the drug FEXADIN is based on officially approved instructions for use and approved by the manufacturer.

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Source: https://health.mail.ru/drug/fexadin/

Reviews

Maria, 23 years old

In the spring I constantly suffer from hay fever - I sneeze when the trees bloom. To get rid of allergy symptoms, ideally I would need to leave this area for a while, but work doesn’t let me go, so I take Fexadin tablets. They quickly eliminate sneezing, itching of the skin and nose, and prevent swelling of the mucous membrane in the nose and mouth from developing. I like the drug!

Andrey, 32 years old

I have chronic allergies to dust and cat hair. When I visit friends who have a cat, I take antihistamine tablets in advance. I buy Fexadin more often - I like that the drug is affordable and does not cause drowsiness or addiction. The effect of the product is excellent, there is no sneezing, no watery eyes, no allergic rhinitis and cough.

Maxim, 41 years old

Last year I was diagnosed with pityriasis rosea. The skin on my arms, legs and back itched terribly and was unpleasant to touch. Doctors prescribed a comprehensive treatment, which included antihistamines. I took Fexadin tablets to eliminate hives and itchy skin, they effectively helped get rid of these unpleasant symptoms.

Anna, 28 years old

My husband was diagnosed with psoriasis. I know that this is a practically incurable disease, so we can only hope for remedies that alleviate the symptoms. To eliminate itching and inflammation, the doctor prescribed Fexadin tablets to my husband. They were weak, but they helped ease the exacerbations. If I stop helping, we’ll go to the doctor and ask for others.