Fluconazole is a medication used to treat fungal diseases.
In addition to its therapeutic effects, Fluconazole contains properties that can negatively affect the health of the body. This is due to the fact that it contains inhibitors that provoke allergies. Its consequences can be expressed in the form of Steven-Johnson and Lyell syndromes, exudative erythema. Due to the severity of allergy complications, patients are sometimes admitted to intensive care.
What is this
Some people believe that allergies are a very complex chemical and biological process that is inaccessible to the understanding of the general public. This opinion is erroneous; any allergic reaction is simply an attempt by the immune system to protect itself from a foreign substance that poses a threat.
If the immune system works correctly, then allergy symptoms do not occur, but in the presence of pathology, a malfunction occurs, and those compounds that are not only harmless, but also benefit a person, are mistaken for hostile elements.
Medicines contain a huge number of chemical compounds; it is not surprising that allergies to medications are one of the most common. As soon as the “hostile” substance enters the blood, the release of histamine begins. The task of this hormone is to remove the allergen and eliminate the threat. But what happens instead is that histamine reacts with the irritant, and the compound begins to provoke the development of symptoms of an allergic reaction.
Important! Allergy to Fluconazole often occurs in alcoholics, people with infectious pathologies, children, pregnant women and other patients whose immunity is weakened.
Types of itching
After treatment for thrush, you may experience several types of itchy sensations. And each of these varieties will indicate its own reason. Let's take a closer look at how itching manifests itself after thrush, and what it may be associated with.
Moderate
This itching is quite bearable. Mild irritating sensations that remain after antifungal therapy are most often ignored by women, believing that they will soon go away on their own. Sometimes this happens, but sometimes when the immune system is weakened or in the presence of other provoking factors, the incompletely treated fungus begins to multiply rapidly again. Moderate itching most often bothers a woman at night, as well as during and immediately after urination.
Growing
This itching is moderate at first, but its intensity increases, which indicates a new round of thrush. At times the itching and burning sensations are unbearable.
Strong
With this option, the woman suffers the most. In this case, the itching is constant, severe, and unabated. Unpleasant sensations in this case cause a lot of problems and discomfort. The itching intensifies at night and leads to insomnia, irritability, fatigue, and other consequences of regular lack of sleep.
Causes
The inhibitors included in Fluconazole block harmful cells, reducing their activity. As a result, the patient's well-being is improved. It is these inhibitors that in some cases cause an allergic reaction. The immune system reacts to them, the release of histamine begins, and allergy symptoms develop.
Another common cause is drug overdose. In this situation, the medicine begins to cause very real harm to the body, poisoning occurs. The immune system fights this problem and allergies develop. The mechanism of its occurrence is exactly the same as with intolerance to inhibitors.
Peculiarity! Drug intolerance is sometimes caused by genetic reasons, that is, it is inherited. In this case, an allergy to Fluconazole is very difficult and takes a long time to treat, and sometimes healing becomes impossible; a person is forced to live with this disease all his life, periodically turning to doctors to look for an analogue.
Treatment of an allergic reaction to fluconazole
First, you should find out what allergens are present in the medicine. After determination, it is necessary to exclude the use of products containing them in their composition. Allergies should be treated with medications. Taking into account the patient’s condition, the need for it is determined by a specialist.
Important! To provide timely assistance for anaphylactic shock, you need to urgently administer epinephrine to the patient and call an ambulance. Apply an ice compress to the injection area.
Afterwards, bronchodilators and agonists are used. Antihistamines are used to eliminate skin manifestations.
Symptoms
The symptoms of this allergic reaction are very extensive and manifest themselves quite clearly. In some cases, this helps to quickly make a diagnosis, but sometimes it is precisely this circumstance that confuses the doctor, especially if the patient has ingested a large number of potential allergens in a short time.
The most common signs of an allergy to Fluconazole:
- Skin rashes (blisters, hives, as in the photo). The rash is most often localized on the abdomen, but can spread to other areas of the body.
- Swelling of the arms and legs.
- Burning sensation on the mucous membranes.
- Abdominal pain accompanied by intense thirst.
- Labored breathing.
- Asthmatic attacks.
- Quincke's edema (the most dangerous symptom, can lead to death from suffocation).
There is also often a constant desire to empty the bladder. In some cases, going to the toilet goes without incident, but sometimes urination becomes difficult.
What does fungus look like on the face?
Medical science distinguishes several types of mycosis; in the photographs of patients, the difference between sizes, shapes and contours is visible:
- Trichophytosis - expressed in the form of large round spots. The edges of the wound look like inflamed ridges. In the infected area, scaly nodules are visible, which without treatment turn into ulcers. Changes in weather provoke illness.
- Ringworm multicolored - appears as small pink spots. If left untreated, the spots unite and change color to brown.
- Seborrheic dermatitis - originates from the scalp. At the initial stage, small inflamed areas form. They are covered with scales or hemorrhagic crusts. Burning itching is characteristic; scratching the wounds leads to secondary infection.
- Rubromycosis is characterized by dilation of blood capillaries. At the last stage, crusts form.
- Microsporia - infection occurs from sick animals or contaminated soil. The infected part peels off, eventually becoming covered with crusts and ulcers.
In men, mycosis most often finds refuge in the mustache and beard area. The so-called parasitic sycosis. The hair follicles become inflamed, blockage and suppuration occur.
Diagnostics
In most cases, diagnosing an allergy to Fluconazole does not cause problems - the symptoms are clear, and if the history confirms information about taking a dangerous drug, the conclusion becomes obvious, you can begin treatment.
But not everything is so simple - the symptoms described above may be characteristic of a number of infectious diseases, as well as allergic reactions of a different nature. There is a need to exclude or confirm these causes of illness.
One of the main means is blood tests for:
- infection;
- IgE;
- histamine.
After receiving the results of the study, you can safely begin treatment.
Features of allergies
Fluconazole is a medication used to treat fungal diseases.
Causes of allergies:
- alcoholism;
- interaction with other medications;
- individual intolerance to fluconazole;
- food allergy.
Fluconazole is prescribed for diseases such as:
- AIDS;
- cryptococcal infections;
- non-invasive candidiasis;
- candidiasis;
- candermia;
- fungal infections;
- for oncological diseases;
- shingles;
- skin fungus.
Reviews
Irina : “Fluconazole made me feel like Angelina Jolie. I took Fluconazole, and two hours later my lips became swollen. Believe it or not, they actually looked like two sausages! I came home from work, and my husband laughed and compared me to an American star. I had to take antihistamines.”
Olga : “About 2.5 hours after taking the drug, a rash covered my body, it all started to itch very much, and a burning sensation occurred. I immediately realized that this was a reaction to Fluconazole. Knowing that people are often allergic to this drug, I immediately took Suprastin and felt much better.”
Natalya: “ I started getting thrush. They recommended taking a Fluconazole capsule. I didn’t read the instructions, but in vain. The next morning, my palms were covered with strange red spots that hurt and itched, I didn’t know what to do. Nothing helped! She saved herself with Vinilin - she lubricated the blisters with it.”
How to get rid of fungus on the face?
And even faster, because the fungus spoils our appearance!
But it is very important to understand and realize that you must undergo a full course of treatment, otherwise the mycelium can penetrate inside the body.
Only after drawing up a complete clinical picture will the doctor determine a treatment plan and prescribe medications.
Such points as the patient’s age, general condition of the body and information collected in the anamnesis are taken into account.
Complex treatment includes:
- Vitamin complexes.
- Antihistamines (allergy tablets).
- Antifungal agents (ointment and cream for fungus on the face).
- Allylamines - destroy fungal cells.
- Azoles - stop cell growth.
- Enzymes for gastrointestinal flora and probiotics.
The most effective antifungal drugs that can cure fungus in an adult:
- Benzyl benzoate ointment, course of treatment 4 days. Apply to a clean body before bed.
- Miconazole ointment, course of treatment 7 days. Apply twice a day until completely absorbed.
- Mycoquet ointment, course of treatment 14 days. Apply once every 24 hours.
- Face cream Candide. The active ingredient is clotrimazole. A broad-spectrum drug. Works at different stages of damage. The course of treatment is from 7 days to 30. Apply twice a day in a thin layer.;
- Orungal capsules (analogue of Orungamin), course of treatment for at least 3 months. Orungamine should be taken after meals, twice a day.
Fungus on a child’s face should be treated with gentle medications:
- Terbinafine. Appointed from 2 years. The dosage is calculated based on the child's weight.
- Clotrimazole. Apply to the sore spot once a day.
- Miconazole. For children under three years of age, use the drug strictly under the supervision of a pediatrician. Apply twice daily.
Important!!! Almost all antifungal medications are quite strong and can harm your body. To reduce the harmful effects on the body, it is recommended not to delay starting treatment. In the early stages, the pharmacological “artillery” will be much smaller.
Folk remedies for combating facial mycosis
- Lemon juice. Rub it into the affected areas overnight and wash your face with warm water in the morning. The acidic environment actively fights fungal spores.
- Horsetail tincture. Wash your face 4 times a day.
- Celandine. Brew a liter of water with 3 tbsp. dry herbs and also wash your face several times a day.
- Raisin. Wipe the affected areas with it.
- A mask of garlic paste (3 cloves) and butter (half a teaspoon) is applied for half an hour, then washed off with warm water.
- Honey. Dissolved in water (1:10).
- Onion juice mask. Apply to the skin and wash off with warm water after 10 minutes. It is advisable to carry out the procedure on weekends, as the onion smell is quite persistent.
This is interesting! Sometimes, from prolonged contact with the sun, the disease goes away on its own. White spots remain on the skin.
For prevention, just lead a healthy lifestyle, eat less sweets and starchy foods. Less stress and more smiles. And be sure to undergo an annual examination with a doctor to identify chronic diseases. Without proper treatment, the disease lasts for months. Scars and scars may remain on the body. In addition, there may be other consequences:
- allergic reactions of the body;
- spread of infection to nearby areas of the body;
- mycosis can cause complications in the form of diseases of internal organs;
- high risk of damage to blood vessels.
How to treat and replace
The first step is to abandon traditional methods of treatment. Of course, some of them are indeed not effective, but in some cases there is a significant risk of provoking a new allergic reaction, in comparison with which the problems caused by Fluconazole will seem like a cakewalk. In addition, you should not determine your own therapeutic strategy; all treatment methods must be prescribed by a doctor!
First you need to cleanse the body of the irritant. For this, enterosorbents are used: Polysorb, Enterosgel, as well as regular activated carbon. In this case, you should drink as much water as possible, in which case the symptoms will be less pronounced and the person will feel better.
If the symptoms are very severe and the patient begins to choke due to angioedema, then you need to immediately call an ambulance and give the victim a dose of any antihistamine:
- Suprastin;
- Zodak;
- Claritin;
- Zyrtec.
After the ambulance arrives, the patient will be out of danger, but you should not refuse hospitalization - the patient should be under the supervision of specialists for some time.
The main preventive measure is to replace a dangerous drug with an analogue that has a similar effect on the body. Such means include:
- Diflucan;
- Flucostat (a similar allergy may develop);
- Fluzon;
- Diflazon.
You should not select a replacement yourself; you should consult a specialist. After replacing the drug, you need to take a prophylactic course of antihistamines. They can be used not only when symptoms occur, but also to prevent exacerbation of the disease. Please note that such products should not be taken by pregnant women and young children.
How is the medicine prescribed?
The medicine is prescribed for the prevention of secondary fungal infections in patients with HIV, people who regularly take corticosteroids, and patients with congenital immunodeficiencies. People with cancer who have undergone radiation treatment need to eliminate fungal infections. This drug is used in the treatment of candidiasis of various origins.
Other indications include:
- endocarditis;
- thrush;
- candidal balanoposthitis;
- fungal prostatitis;
- septicemia.
Important! You can start a therapeutic course only after prescribing the drug by a specialist.
Features of the course in children
Most often, a child has a fungal allergy in the months of March-November, since this period is marked by the most unfavorable weather conditions. This deviation often becomes the source of childhood conjunctivitis, dermatitis, and eczema. If you are allergic to a fungus, parents discover the following symptoms in your baby:
- frequent discharge of mucus from the nose;
- multiple sneezing and nasal congestion;
- increased lacrimation;
- night cough and shortness of breath;
- wheezing and heavy breathing at night;
- blood from the nose.
Some time after the manifestation of the above symptoms, the child weakens, he has dark circles under his eyes and pale skin. Due to the decline in the protective functions of the immune system, the child quickly gets tired and feels constant weakness. If a child with an allergy to fungus is not treated promptly, mycoses and abnormalities of the cardiovascular system will soon arise.
Fluconazole - analogues: which is better - Diflucan, Flucostat, Nystatin, Mikosist, etc.
Today, there are dozens of fluconazole analogues on the pharmaceutical market of the Russian Federation.
They all differ in price, many in quality, release form, dosage and manufacturer. Some have European quality standards (GMP, etc.), some do not. Let’s immediately define the concept of “analog” - in the pharmaceutical market the term generic or generic drug is more often used. This is a substance “copied” from the molecule of the company that invented the active substance.
Only one drug on the market is “that” first drug on which all clinical studies were conducted, with proven quality and clearly recorded dosages, side effects and contraindications.
A little history of the issue
Invention of the original drug
So, the first manufacturer of fluconazole to be released onto the pharmaceutical market was Pfizer (USA). Currently, the drug of this company in Russia bears the commercial name Diflucan, and all other fluconazoles on the market in our country are its copies (generics).
The generic repeats the formula of the original drug, passes some tests for compliance with the original (pharmacokinetics are compared, sometimes pharmacodynamics are compared) and is considered its complete analogue, it can project all the advantages and disadvantages of a specific active substance onto itself, i.e. All generics of Diflucan and Diflucan itself are considered fluconazoles.
The original drug is always more expensive, which is explained by the costs of invention, research and implementation of a new molecule.
For this reason, the original drug has a certain period during which patent protection prevents the emergence of generic forms. After this, a certain number of copies appear from different manufacturers.
The more in demand the drug is, the more copies there will be. There are more than 30 fluconazoles in Russia, for example.
Generics are usually cheaper. In addition, the smaller the manufacturing company, the more liberties it can take in the process of registering and introducing its product. It happens that a generic product from some little-known Indian company has advantages that even the original product does not have.
It is important to understand that all existing studies of any active substance were carried out exclusively on original drugs, so the generic does not and cannot have any additional advantages.
Drug development
In addition, unscrupulous manufacturers deliberately distort contraindications and side effects for the product in order to capture one or another market segment.
So, a generic cannot be better than the original drug, but it can cost significantly less. Insurance medicine in developed countries quite strictly regulates the prescription of original drugs and generics. As soon as the patent expires, the doctor switches to high-quality generics, since this reduces the cost of treatment with comparable effectiveness.
Why original drugs are more effective than generics
- Only high-quality (original) substance is used - fewer impurities, therefore fewer possible side effects, allergic reactions, etc.;
- Standards for storage and delivery of the product to the consumer are observed;
- Thanks to the work of the manufacturer’s external service, doctors know the specifics of use and correctly prescribe original drugs (in addition, many doctors consider working with an original drug to be prestigious).
Generics
Why some generics do not have the required therapeutic effect
- Substance of low quality. Currently, China, Pakistan and India produce huge amounts of feedstock. In terms of profitability, the sale of medicines is approaching the arms and drug trade, and corruption in this segment is simply terrifying. For this reason, tons of drugs with low quality substances are imported into the country every day.
You should not buy fluconazoles made in India, companies from Cyprus and some domestic manufacturers (raw materials are purchased there).
- The packaging technology is not followed, or the storage regime of the drugs is violated.
- Well-known brand (Europe, Russia, USA). Large companies try not to buy raw materials of questionable quality;
- Average price niche. Very cheap drugs imply low quality. The high price for a generic is not acceptable, this indicates a lobby for the drug among doctors;
Generic drugs, for example, from the KRKA company, in some cases can be close in price to the original ones. This is not due to exclusive quality, but to the marketing efforts of medical representatives (the company's external service).
- Availability of the drug in pharmacies. If it is available in all pharmacies, you are prescribed a proven, high-quality product. You should not look for a rare type of fluconazole, since the active substance has been on the market for quite a long time, and there is nothing exclusive in such a prescription, other than the gratitude of the pharmaceutical company to a specific doctor.
The comparison is made based on the most common dosage of fluconazoles – 150 mg No. 1 (one capsule).
Diflucan is the original drug. If the doctor prescribes it, and the amount is not critical for you, buy it with confidence. Cost from 500 rub. Traditionally, it is believed that a generic should be at least 2 times more accessible than the original. Prices are indicative only to visualize the relationships between different manufacturers.
- Mikosist. Gedeon Richter (Hungary) is a well-known European brand, high quality - from 300 rubles;
- Flucostat Pharmstandard OJSC domestic brand, price from 190 rubles;
- Diflazon KRKA (Slovenia) is a well-known generic company operating primarily in the CIS market. The quality is not bad, the price starts from 250 rubles;
- Mycomax Zentiva (Czech Republic). The quality is good, price from 230 rubles;
- Mycoflucan Reddy's Laboratories Ltd. (India). To the credit of this company, I would like to say that it is one of the few Indian companies that produces high-quality generics. You can safely take mycoflucan, price from 190 rubles;
- Fluconazole VERTEX (Russia) price for 150 mg No. 2 (2 capsules) is up to 50 rubles. Of course, for this money you get the appropriate quality of the product. It cannot be said that absolutely all prescriptions of this kind are ineffective, however, it is not worth replacing Diflucan with fluconazole from VERTEX - resistance to the active substance may develop, and the effect will not be achieved.
The use of cheap generic fluconazole can cause the pathogen to become resistant to all drugs, not only fluconazole itself, but also the triazole group as a whole. As a result, such candidiasis is subsequently extremely difficult to treat.
- Fluconazole-Stada (STADA AG concern). An international concern that includes 4 separate companies. Positioned as a domestic manufacturer (European standards). The quality is acceptable, price from 80 rubles;
- Flucostat Pharmstandard-Leksredstva (Russia). Domestic quality, price from 200 rubles.
Thus, an acceptable price for 1 capsule of 150 mg of fluconazole is in the range from 100 to 300 rubles. An adequate purchase would be products from Zentiva, KRKA, Dr. Reddy´sLaboratoriesLtd. If funds are tight, one of the best offers is Fluconazole-Stada.
Fluconazole has fairly broad indications for use, but it is mainly prescribed for vaginal candidiasis. Most patients experience episodes of candidiasis more than once a year.
For this reason, it is worth purchasing fluconazole No. 5 or No. 7, since a single dose for chronic candidiasis does not give much effect, and doctors, when recommending the drug for several doses, do not always mention the availability of this form of release.
For chronic candidiasis, it is much more profitable to buy a package of five 150 mg capsules.
For better effect after treatment of vaginal candidiasis, it is advisable to use vaginal forms of probiotics, since killed fungus does not mean immediate colonization of the vagina by normal flora, which creates a risk of relapse of the pathological process.
Fakes
When buying a drug from a well-known manufacturer of fluconazole at a pharmacy, pay attention to the original packaging, instructions, blister and the capsule itself. Drugs in this group are counterfeited quite often, and the turnover of counterfeit pharmaceuticals in the CIS countries is quite large. Low effectiveness of treatment is often associated with counterfeits.
Of course, the most popular, expensive, branded drugs are counterfeited. Pharmaceutical pirates do not often pay attention to generics of the middle and lower price niche, which is another argument for purchasing them.
When purchasing a drug at a pharmacy, always keep the receipt and packaging. This can help you and your doctor recognize a fake, if the fungicidal therapy is ineffective, which will allow you to adequately adjust the treatment plan in the future. Otherwise, you may refuse one of the most effective remedies for fungal infections without good reason.
about fluconazole
- Alexandra
Source: https://med-look.ru/analogi-flukonazola-i-ix-otlichiya-za-chto-platit-bolshe.html
What fungal diseases cause allergies?
Black mold
Black mold fungi are mainly located on walls in damp rooms and have an unpleasant odor. This fungus contains viruses and bacteria that aggravate allergies in humans. Doctors say that black mold is the most allergic and poses a great threat to health. If this type of fungus is found in the human body, it is necessary to find out its origin; only in this case will it be possible to overcome allergies and completely get rid of the fungus in the body.
Red mold
This type of mold is usually found on cereal crops. Considering the growing season of the year, different forms of red mold will appear:
- in hot weather, trichocetins influence the appearance of mold;
- During the wet period, fungi appear due to vimotoxins or zearalenone.
Fungi in food
Molds formed on food products pose a significant danger, since due to the activity of microorganisms they become toxic. If such carcinogenic substances accumulate in the human body in large quantities, this can cause cancerous tumors. It is strictly forbidden to eat meat, fruits, vegetables, baked goods on which mold has formed.
The itching does not go away after fluconazole
Thrush and my fight against it!
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At that time it was somehow not very strong, but then on the evening of November 3, a terrible itching began, with a strong, curd-like discharge.
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Misspoem
Pimafucin
The evil aunt, thrush overtook us too.(((Before pregnancy, it happened no more than 2 times, and I coped with one Fluconazole tablet (so it seems). But now I can’t drink it and the gynecologist said to be treated ONLY with Pimafucin.
I bought a cream (there were no suppositories) and applied it for 3 days - the itching did not go away ((I went for pills. Today I started, so to speak, complex treatment.
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Catherine
Fluconazole, to be or not?
I’ve already lost count of which cycle we’re planning. Last cycle I was on antibiotics. Today is day 1 of a new cycle and a lot of thoughts and plans. Thrush didn’t seem to show up after ab, maybe the suppositories helped somehow (I put rumizol). But when washing my face I still get such thick leucorrhoea.
I’m wondering if thrush always goes away with itching and a cheesy discharge? Should I take a fluconazole capsule with my husband as a preventive measure? I was also thinking about Acilact suppositories, but they are only possible if there is no thrush) Is it worth going for experiments...
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Lena_licht
About sexually transmitted infections
Recommended reading for younger sisters, growing up daughters of friends and romantically minded young girls. I never thought that I would write about such banal things, but I have to. Everything, as always, is from life examples. Yesterday the administrator asked to see the patient without an appointment.
Ok, I'll take a look. Girl O, born in 1995 - 21 years old. Works, studies. Tells a story - 6 weeks ago a new partner appeared. Life is wonderful, sex is too; only after the first time very unromantic signs appeared - itching and, sorry, discharge from...
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Konfetochka
How did I get to fluconazole... I don’t even know what category to put this post in!
About seborrhea, bad dermatologists, Laura and such strange treatment.
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Olesik
Expensive medicines and cheaper analogues
Belosalik and Akriderm SKBepanten and DexpanthenolBetaserc and BetahistineBystrumgel and KetoprofenViagra and DynamicVoltaren and DiclofenacGastrozol and OmeprazoleDetralex and VenarusDiprosalic and Akriderm SKDiflucan and FluconazoleDlynas and RinostopZantac and RanitidineZyrtec and CetirinaxZovirax and A cyclovirImmunal and EchinaceaImodium and LoperamideIodomarin and Potassium iodideCavinton and VinpocetineClaritin and LoragexalCLACID and ClarithromycinLazolvan and AmbroxolLamisil and TerbinafineLioton-1000 and Heparin-acri gel 1000 Lomilan and Loragexal Maxidex and Dexamethasone Mezim and Pancreatin Mydriacyl and Tropicamide Miramistin and Chlorhexidine Movalis and Meloxicam Neuromultivit and Pentovit No-shpa and Drotaverine Normodipine and Amlodipine Nurofen and Ibuprofen Omez and Omeprazole Panadol and Paracetamol Pan ngin and… Read more →
Dena
Emergency situations (God forbid)
It’s better to not need it than to not have it... Read more →
Everything about the girl
Girl: everything you need to know about her “Already little girls reveal in their attitude towards the doll such caring and subtle sensitivity to the substantive details of care that they seem to be surrounded by a genuine aura of motherhood.
The boy treats the doll completely differently. He makes his doll jump and march, sits as a rider in a cart, rides on toy animals, and soon abandons it.” IN.
Stern, German psychologist Read more →
Ruslana
The long-awaited second entry
I promised to write on Friday (10/26/12), but I’m only writing today. Well, I donated additional blood from a vein for hormones. It cost 280 UAH, apparently, in the same children's clinic.
On the weekend we went to our parents to pick up the car, and drove back on our own wheels - it’s so cool, I tell you). On Tuesday and Wednesday I got the results. My hormones are all within normal limits, which made me very happy. I really didn’t want to take anything hormonal, because...
this interference is often irreparable. Papilloma virus… Read more →
Source: https://www.BabyBlog.ru/theme/posle-flukonazola-zud-ne-prohodit