Some facts
The main component of the drug is fexofenadine.
Work on its synthesis was carried out in several laboratories at once, and scientists first brought it to perfection in 1993 in the USA. Its formula consists of thirty-two carbon molecules, thirty-nine hydrogen molecules, one nitrogen molecule and four oxygen molecules. Allegra was created to relieve inflammation of the nasal mucosa, which occurs due to allergens. It effectively removes swelling of the mucous membrane, nasal congestion, and burning sensation. Reduces mucous discharge and sneezing. An effective remedy in the fight against different types of allergic processes (seasonal, chronic, food, medication).
Contraindications Allegra tablets 180 mg
Chronic idiopathic urticaria (to reduce symptoms).
Hypersensitivity to any of the components of the drug. Pregnancy. Lactation period Children's age (up to 12 years).
Allegra's indications are the treatment of inflammatory processes in the nasal mucosa due to various types of allergies. The medication is indicated for the treatment of seasonal allergies (during the flowering of plants and trees). The remedy is effective in patients with chronic forms of urticaria. It is used to treat the allergic process, which manifests itself in the form of red blisters of different diameters throughout the body.
Contraindications for Allegra are the presence of increased sensitization to the constituent elements, pregnancy and lactation, age under twelve years. Used cautiously in patients with impaired kidney and liver function, and in people of retirement age. Also do not use or use under medical supervision in patients with heart disease.
Allegra - instructions for using allergy pills
Most antihistamines have a sedative effect on the body and mental activity. Almost every anti-allergenic drug contains histamine, which interferes with the body's normal production of special chemical elements in response to allergens.
Allegra tablets are an original medicine that differs significantly from other drugs; its active substances eliminate allergy symptoms and facilitate the functioning of basic internal systems.
In this article we will look at the effect of the drug Allegra, its indications and treatment methods.
Pharmacological action and release form
Allegra is an antihistamine that contains fexofenadine.
This active metabolite does not have an alpha-adrenergic blocking effect, which excludes sedative effects and other effects of the central nervous system.
Studies of the drug have shown that after oral administration of the drug, fexofenadine begins to act within 1 hour, and after 6 hours it reaches its maximum.
For information! It is important to note that Allegro tablets were called Telfast until 2014.
In patients with seasonal allergic manifestations receiving 240 milligrams of fexofenadine daily for 2 weeks, improvements in the body's performance were noted.
It is worth noting that the active component is practically not metabolized in the liver and outside it, and in human feces and urine a high amount of only fexofenadine is observed.
The removal of the active substance from the blood plasma occurs with an exponential decrease (when the growth rate is proportional to the value itself), and the half-life lasts from 11 to 15 hours of the day after prolonged use of the drug.
According to studies, it was revealed that most of the drug is excreted unchanged in bile and urine, which amounts to up to 10%. The drug is produced in tablets coated with a light pink protective coating. The shape of the tablets is oblong, biconvex with an engraving on one side of 012 and the letter “e” on the other.
Instructions for use and composition
Allegra contains the main active substance fexofenadine hydrochloride. Additional excipients of the drug include:
- magnesium stearate;
- pregelatinized starch;
- sodium croscarmellose.
The shell of antihistamine tablets contains:
- iron oxide dye, which contains a yellow mixture;
- iron oxide dye, which contains a pink mixture;
- macrogol;
- colloidal silicon dioxide;
- titanium dioxide;
- povidone;
- hypromellose E15 and E5.
For information! Pink and yellow iron oxide dye is a mixture of red oxide iron and yellow oxide E172 diluted with titanium dioxide E171.
The drug Allegro and its instructions for use imply its use for:
- seasonal allergic manifestations of rhinitis (to reduce symptoms, it is recommended to take 120 mg tablets);
- chronic idiopathic urticaria (to reduce symptoms, it is recommended to take 180 mg tablets);
- allergic conjunctivitis, characterized by tearing, swelling of the eyelids and redness of the eyes.
It is worth noting that at plasma concentrations 32 times higher than the therapeutic concentration, fexofenadine did not have a negative effect on delayed rectifier potassium channels in the human heart.
Side effects
According to clinical studies, the following side effects of the allergy drug were identified:
- drowsiness;
- attacks of headache;
- dizziness;
- attacks of nausea and vomiting;
- nervousness, sleep disturbance;
- tachycardia;
- diarrhea.
For information! In rare cases, the drug can cause a hypersensitivity reaction of the skin, which manifests itself in the form of itching, exanthema and urticaria.
Among the contraindications of the antiallergic drug, the following can be noted:
- hypersensitivity to the main and additional components of the drug;
- lactation period;
- pregnancy, regardless of trimester;
- children under 12 years old.
It is recommended to use the drug with caution in patients with liver and kidney failure, the elderly, and patients suffering from cardiovascular pathologies, including a history of it.
Directions for use and doses
The drug is intended for oral administration; the instructions indicate a clear dosage that allows you to eliminate the external symptoms of an allergic reaction. Allegro - instructions for use:
- For seasonal exacerbation of allergic rhinitis, it is recommended to take 120 mg 1 time per day before eating. The tablet is engraved with 012 on one side and the letter “e” on the other side;
- For chronic urticaria, it is recommended to take 180 mg once a day before meals. The tablet is engraved on one side with 018 and on the other side with the letter “e”;
- For allergic diseases in children, it is recommended to take 30 mg of the drug.
For information! There should be a break of at least 2 hours between taking Allegra and other antacid medications.
It is recommended to store antiallergic medicine in a dry place, at room temperature and with good ventilation.
Analogues of the drug
Allegra has analogues of the drug, which also contains the main active substance - fexofenadine hydrochloride. The most common medications include:
- Nafcon;
- Vazocan;
- Claritin;
- Allegra D;
- Semprex;
- Fexadine.
It is worth noting that analogues may contain a lower dosage of the active substance.
The drug Allegro is a modern antiallergic drug that can comprehensively eliminate the external manifestations of allergic diseases. If you follow the correct dosage and all the recommendations of your doctor, you can get rid of allergens and increase the functionality of the main body systems.
Source: https://IDermatolog.ru/preparaty/ot-allergii/allegra-tabletki.html
Pharmacological properties
Allegra is an antihistamine. Its main effect is the suppression of allergens in the blood. The drug blocks H1 receptors and does not inhibit the state of the central system. The medicine effectively blocks the blockade of biogenic amine receptors in the body, their activity decreases. The most common histamines manifest themselves in the form of altered functioning of organs and systems.
Swelling of the mucous membrane, spasm in the bronchi, itching and red blisters all over the body appear. Sometimes histamine can affect the functioning of the gastrointestinal tract - colic appears, gastric secretion changes. Histamine also affects the heart (blood vessels dilate, their permeability increases, blood pressure increases, and heart rhythm is disturbed).
An increase in its exposure causes allergies, so the medicine first relieves allergy symptoms, then the process of regeneration of the body begins. Maximum allergen suppression is up to eighty percent. In the treatment of seasonal diseases, the drug does not affect potassium channels.
After ingestion, the medicinal component is well absorbed into the cells of the body. The maximum speed is up to three hours. The maximum concentration is two hundred eighty-nine nanograms per milliliter (when taking one hundred and twenty milligrams of the drug). The active component binds to plasma proteins, the connection is up to seventy percent.
The active component is metabolized in small quantities in the hepatic system. It passes into urine and feces. Elimination occurs after fifteen hours. Ten percent is excreted in urine, and the rest in bile and feces. Patients with impaired renal function do not require adjustment of therapy.
The medication does not have a toxic effect on the heart. The intake between different medicinal substances lasts from two hours, then the active component goes through all transformation processes without change. The medicine does not change consciousness and attention, so while taking it you can drive vehicles and perform work that requires increased attention.
Method of use and dosage Allegra tablets 180 mg
The drug is taken orally. The tablets can be taken with water, but drinking fruit juice is not recommended. Dosage for children and adults depends on the severity of the disease. It is installed by the attending allergist. The medicine is taken before meals. The duration of therapy is individual for each patient. Patients with impaired liver and kidney function do not require treatment adjustments.
An overdose of Allegra manifests itself in the form of dizziness and drowsiness. Some patients experience dry mouth. If an overdose of the drug occurs, you should stop taking it and seek help from a doctor. Before the ambulance arrives, you can take activated charcoal. The doctor will prescribe symptomatic therapy until the symptoms of overdose disappear.
The tablets are intended for oral administration. The recommended dose of fexofenadine for chronic urticaria for adults and children 12 years of age and older is 180 mg once daily before meals. Studies in special risk groups (elderly patients, patients with renal and liver failure) have shown that they do not require adjustment of the dosage regimen.
Allegra price in Tomsk from 498 rubles, buy Allegra, reviews and instructions for use
Currently, there are no drugs used to treat allergies that would definitively cure the patient. As a rule, therapeutic treatment is aimed at relieving acute symptoms and preventing subsequent complications.
To relieve the complex symptoms of the disease, medications that have a mixed type of effect are often used. The bulk of drugs contain histamine and interfere with the release of chemical elements that the body produces in response to allergens.
Allegra (fexofenadine hydrochloride) is different from these drugs. It contains only antihistamines in combination with decongestant components, which facilitates the functioning of the body.
These are original antihistamine tablets with the active ingredient: Fexofenadine, which is effective for 24 hours and differs from other drugs in the absence of a sedative effect. It is important to note that this drug was called Telfast until 2014, and after that time it was renamed and received the name Allegra.
Release form and composition
Dosage forms of Allegra:
- Film-coated tablets: biconvex, oblong, light pink in color, on one side there is an engraving (depending on the dose) “012” or “018”, on the other there is a stylized letter “e” (10 pieces in blisters, 1 blister in a cardboard box);
- Film-coated tablets (for children): biconvex, round, light pink, engraved “03” on one side, the stylized letter “e” on the other (10 pcs. in blisters, 1 blister in a cardboard pack ).
Composition of 1 tablet:
- Active substance: fexofenadine hydrochloride – 120 or 180 mg;
- Auxiliary components (120/180 mg): croscarmellose sodium – 24/36 mg; pregelatinized starch – 120/180 mg; microcrystalline cellulose – 133/199.5 mg; Magnesium stearate – 3/4.5 mg;
- Film coating: hypromellose (E15) – 2.84/4.26 mg; hypromellose (E5) – 1.89/2.835 mg; povidone – 0.51/0.765 mg; titanium dioxide (E171) – 2.025/3.038 mg; colloidal silicon dioxide – 0.73/1.095 mg; macrogol 400 – 3.94/5.91 mg; iron oxide dye (pink mixture - a mixture of red iron oxide (E172) and titanium dioxide (E171)) - 0.025/0.038 mg; iron oxide dye (yellow mixture - a mixture of yellow iron oxide (E 172) and titanium dioxide (E 171)) - 0.04/0.06 mg.
Composition of 1 tablet for children:
- Active substance: fexofenadine hydrochloride – 30 mg;
- Auxiliary components: pregelatinized corn starch, croscarmellose sodium, magnesium stearate, microcrystalline cellulose;
- Film coating: hydroxypropyl methylcellulose (hypromellose) E-5, hydroxypropyl methylcellulose (hypromellose) E-15, iron oxide color [pink and yellow mixture], anhydrous colloidal silica, povidone, macrogol 400, titanium dioxide.
Method of use
Allegra should be taken only after being prescribed by your doctor.
- Any medicinal dose is washed down with plenty of boiled water;
- Recommended medication intake: 2 times;
- It is undesirable to use fexofenadine in combination with drugs that contain magnesium and aluminum. These include: Maalox, Rolaids, Magnesia, Milanta, Pepcid, etc. These medications can minimize the activity of Allegra;
- You cannot independently increase or decrease the dosage of the drug, especially with concomitant heart, kidney and liver diseases, when the dosage of the tablet is selected according to a special scheme;
- the drug is included in category C, relative to the FDA, which means that the harmful effects of the drug on the fetus during the patient’s pregnancy have not been proven. However, its prescription should be done very carefully and only after prior consultation with your doctor. In addition, the same restrictions exist for women who are breastfeeding;
- The use of the drug is not permitted if there is an individual intolerance to it.
Fexofenadine hydrochloride should not be prescribed in cases where maximum concentration and rapid response are required from the patient. This is especially true for drivers, train drivers, pilots, etc.
Contraindications
Absolute:
- Ages up to 6 years (for tablets for children) and up to 12 years (for tablets);
- Pregnancy and lactation;
- Hypersensitivity to the components of the drug.
Relative (Allegra is prescribed with caution in the presence of the following diseases/conditions):
- Chronic liver/renal failure (due to limited clinical experience with the drug in this group of patients);
- Old age (due to limited clinical experience with the drug in this group of patients);
- Cardiovascular diseases, incl. history (Allegra can cause tachycardia and palpitations).
Side effects
Side effects include headache, dizziness, increased need for sleep, nausea or vomiting. Some people experience sleep disturbances, increased excitability, rapid heartbeat, and digestive disorders. In rare cases, an allergic reaction occurs in the form of urticaria, itching and burning, Quincke's edema, a feeling of lack of air, and redness of the skin. If an undesirable effect on the body occurs, stop taking it and begin symptomatic therapy with a doctor.
Side effects
In placebo-controlled clinical trials, the most commonly observed (≥1% - {amp}lt;10%) were headache (7.3%), drowsiness (2.3%), dizziness (1.5%) and nausea (1.5%).
https://www.youtube.com/watch?v=ytpolicyandsafetyru
When taking fexofenadine, the incidence of the above adverse effects was similar to that when taking placebo.
In placebo-controlled studies with an incidence of less than 1% (the same for fexofenadine and placebo) and post-marketing use, the following were observed: weakness, insomnia, nervousness and sleep disturbances or unusual dreams (paroniria), such as nightmares; tachycardia, palpitations; diarrhea.
In rare cases (≥0.01% - {amp}lt;0.1%): exanthema, urticaria, itching and other hypersensitivity reactions, such as Quincke's edema, difficulty breathing, shortness of breath, skin hyperemia, systemic anaphylactic reactions.
When fexofenadine is co-administered with erythromycin or ketoconazole, the plasma concentration of fexofenadine increases 2-3 times, but this is not accompanied by a significant prolongation of the QTc interval. There were no significant differences in the incidence of adverse effects when using these drugs as monotherapy and as part of combination therapy.
There is no interaction between fexofenadine and omeprazole.
Does not interact with drugs metabolized in the liver.
Taking antacids containing aluminum or magnesium 15 minutes before taking fexofenadine leads to a decrease in the bioavailability of the latter as a result, apparently, of binding in the gastrointestinal tract.
