An allergic reaction occurs due to various provoking factors. It is not uncommon to suffer from rashes, itching and redness of the skin. Symptoms may vary, but in any case they reduce the quality of life. We have to look for medications that will help get rid of the pathology. Doctors often recommend Allergozan ointment, because it helps well with an immunopathological response. Before use, it is recommended to familiarize yourself with the contraindications to avoid complications.
Description of components:
Calcium maintains normal permeability of cell membranes, including capillaries, and increases neuromuscular activity. It normalizes the pH of the digestive tract, increasing the activity of enzymes in the stomach and pancreas.
Magnesium is a constant component of the body's enzyme systems and catalyzes enzymatic processes.
Bromelain is a complex of anti-inflammatory and proteolytic enzymes. It eliminates signs of inflammation and dissolves fibrin clots. Bomeline stops the formation of kinins produced during the inflammatory process.
Evening primrose seeds contain gamma-linolenic acid, which stimulates the body's production of prostaglandins - hormone-like substances that play a key role in the stable functioning of the body and affect cell restoration and immunity.
Being the richest source of GLK (gamma-linolenic acid), a fatty acid called essential, this oil has the only alternative in nature - mother's milk.
Quercetin slows the release of histamine and other mediators (such as hyaluronidase and neutrophylisosomal enzyme) from mast cells, basophils, neutrophils and macrophages. It exhibits antioxidant properties and enhances the activity of other antioxidants, including vitamin C. Quercetin suppresses the synthesis of many substances leading to the development of inflammation, reduces the formation of leukotrienes, which have a 100 times stronger inflammatory effect than histamine and are associated with the onset of asthma , psoriasis, atopic dermatitis, etc.
Valerian contains organic acids such as formic, acetic, malic, stearic and palmitic. The root contains valenotriates, bicyclic sesquiterpenes, mertinol, ketones, baldrinal, pyryl-a-methylketone. And, of course, valerian contains various vitamins, micro- and macroelements in large quantities.
Valerian has a sedative, tranquilizing effect on the central nervous system. This is especially important, since any allergic reaction can cause irritability, anxiety, and sleep disturbances in the patient.
The therapeutic effect of valerian is due to its tonic and choleretic effect; the root reduces the excitability of the central nervous system and promotes relaxation of smooth muscles.
The active component of turmeric , curcumin, has anti-inflammatory properties: it reduces platelet aggregation and cyclooxygenase enzymes, which contribute to the formation of inflammatory prostaglandins.
In addition, curcumin suppresses the formation of leukotrienes and other inflammatory mediators. It also stimulates the release of corticosteroids from the adrenal glands, increases the sensitivity of cellular receptors to cortisone, and also prevents its breakdown.
Grape grain extract containing proanthocyanidins has a wide range of pharmacological activities. This includes the ability to increase the intracellular content of vitamin C, reduce capillary permeability and fragility, and bind free radicals. Extract from grape seeds prevents the breakdown of collagen by enzymes secreted by leukocytes during inflammation, including allergies, and by microbes during infections.
Zinc is required for protein synthesis and collagen formation, improves the protective function of the immune system and wound healing. It protects the liver from harmful chemicals and is very important for bone formation. It is a constituent of insulin and many important enzymes, including the antioxidant enzyme superoxide dismutase. At the same time, under the influence of zinc, the activity of enzymes that inhibit redox processes is suppressed and tissue respiration is normalized.
Boron is required for maintaining bone health and for the metabolism of calcium, phosphorus and magnesium.
Silicon is necessary for the formation of collagen required by bone and connective tissues, to maintain healthy nails, skin and hair, absorption of calcium in the early stages of bone formation, and maintenance of elasticity of arteries.
In the absence or deficiency of vitamin E, membrane permeability is impaired, in particular, the release of lysosomal enzymes is hampered, which enhances immune reactions.
Contraindications
The medication has a number of contraindications that should be taken into account. It is worth noting that the cream cannot be used if you are hypersensitive to the active substance. In this case, there is a risk of worsening your health and causing an exacerbation of symptoms. Do not use the ointment if there are burns, dermatosis, or weeping reaction of the dermis.
Contraindications to the use of tablets:
- The period of bearing a child and breastfeeding.
- Glaucoma.
- Prostate adenoma.
- Exacerbation of gastrointestinal ulcers.
- Stenosis.
- Bronchial asthma.
If there are contraindications, you will have to stop using the medication. You will have to find an analogue that is resolved in the presence of a certain problem.
You will have to follow the instructions for use if your doctor has prescribed Allergozan tablets or ointment. In this case, it will be possible to avoid negative consequences.
AllergoVit: composition and release form
The drug is available in capsule form, 60 and 180 pieces in plastic jars. One capsule of AllergoVita contains: - magnesium (chelated form)………………125 mg - calcium (chelated form)………………..250 mg - boron (chelated form)………………..4 mg - zinc ………………………………….7.2 mg – silicon……………………………..10 mg – querticin………………………………10 mg – bromelain……………………………20 mg – valerian root……………………….3.3 mg – evening primrose oil………………………16.7 mg – grape seeds (extract) ………………1 mg – curcumin……………………………1.7 mg – vitamin E……………………………30 mg
Medicinal allergens
In the process of applying allergen-specific immunotherapy, allergens are used that are obtained by extracting active structures from substances that cause sensitization. These extracts contain not only the allergen, but also impurities that affect the quality of the vaccine. In order to improve its quality, various cleaning methods are used, which are constantly being improved.
Modern technologies have made it possible to create quite a lot of medicinal allergens, such as micromite allergens, the epidermis of cats, dogs, pollen allergens and many others. This significantly expands the range of people who can be treated for allergies.
Allergozan tablets, iv, 5 mg No. 30 (10x3)
dyucha speech:
desloratadine;
1 tablet of desloratadine 5 mg;
additional speeches:
microcrystalline cellulose, calcium hydrogen phosphate dihydrate, corn starch, hypromelose, talc, sodium stearyl fumarate, anhydrous silica;
plivkova cover:
Opadry II 33G 205005 blue (hypromelose, lactose monohydrate, titanium dioxide (E 171), macrogol 3350, triacetin, indigo carmine aluminum varnish (E 132), quinoline yellow aluminum Viy varnish (E 104)).
Medicine form
Tablets, coated with spit coating.
Main physical and chemical authorities:
light blue color, round, biconvex tablets, covered with a spitting film, with a diameter of 6 mm ± 0.2 mm.
Pharmacotherapeutic group
Other antihistamines for systemic congestion.
ATX code R06A X27.
Pharmacological authorities
Pharmacodynamics.
Desloratadine is a non-sedating antihistamine drug that has a selective antagonistic effect on peripheral H1 receptors. After oral administration, desloratadine selectively blocks peripheral histamine H1 receptors.
In vitro studies
desloratadine demonstrated its anti-allergic and anti-inflammatory properties on the endothelial cells.
This was manifested by a suppression of the visibility of proinflammatory cytokines, such as IL-4, IL-6, IL-8 and IL-13 from human mastocytes/basophils, as well as a suppression of the expression of cell adhesion molecules P-selectin on endothelial cells itinah. The clinical significance of these precautions still requires confirmation.
In clinical studies of high doses, in which desloratadine was generally kept at a dose of up to 20 mg for 14 days, there were no statistically or clinically significant changes in the cardiovascular system. In a clinical-pharmacological study in which desloratadine was administered at a dose of 45 mg per dose (9 times higher than the clinical dose) for 10 days, there was no increase in the QT interval.
Desloratadine may not penetrate the central nervous system. In controlled clinical studies, when taken at the recommended dose of 5 mg per dose, the supraworld frequency of sleepiness was equal to placebo. In clinical studies, with a single dose of desloratadine at an additional dose of 7.5 mg, there was no effect on psychomotor activity.
In clinical-pharmacological studies, with one-hour drinking alcohol, alcohol-related impairments, such as decreased productivity or increased drowsiness, did not progress. No significant differences were found in the results of psychomotor testing between groups with desloratadine and placebo, either during self-infusion or during one-hour infusion with alcohol.
In patients with allergic rhinitis, desloratadine effectively relieves symptoms such as coughing, nasal discharge and itching, as well as dizziness of the eyes, erythema and redness, and itching of the palate. Desloratadine effectively controlled symptoms and lasted for 24 years.
Desloratadine effectively alleviates the severity of seasonal allergic rhinitis, as can be seen from the patient's summary of the life expectancy assessment for rhinoconjunctivitis. The maximum reduction was observed in items related to practical problems and practical activities that managed symptoms.
Chronic idiopathic kropivyanka was raised from a clinical model with the minds of kropivyanka. Histamine residues are a causative factor in all forms of urticaria, it appears that desloratadine, in addition to chronic idiopathic urticaria, will effectively alleviate symptoms in other forms of urticaria, as recommended at clinical settings.
In two placebo-controlled, 6-year follow-up studies of patients with chronic idiopathic urticaria, desloratadine effectively relieved itching and changed the amount and size of viscera until the end of treatment. what dosing interval.
The cutaneous effect was observed over a 24-year dosing interval. A reduction in soreness of less than 50% was observed in 55% of patients who took desloratadine, compared with 19% of patients who took placebo.
Taking the drug does not show a significant increase in sleep or daytime activity.
Pharmacokinetics.
Soaked up.
Plasma concentrations of desloratadine can be determined 30 weeks after taking the drug.
Desloratadine is well absorbed, the maximum concentration is reached after approximately 3 years; The recovery period becomes approximately 27 years.
The rate of accumulation of desloratadine was determined by the dosing period (approximately 27 years) and the frequency of administration 1 time per dose. The bioavailability of desloratadine was proportional to the dose in the 5 to 20 mg range.
In a pharmacokinetic study in which patient demographics were similar to the general population with seasonal allergic rhinitis, 4% of participants reached higher concentrations of desloratadine u.
These hundreds may vary depending on ethnicity. The maximum concentration of desloratadine was approximately 3 times in the stomach after approximately 7 years, with a terminal dosage period of approximately 89 years.
The safety profile of these patients does not differ from that of the general population.
Rozpodil
. Desloratadine binds moderately to plasma proteins (83-87%). With a fixed dose of desloratadine (5 to 20 mg) 1 time per dose for 14 days, no sign of clinically significant cumulation of active speech was detected.
Metabolism.
The enzyme responsible for the metabolism of desloratadine has not yet been identified, so it is impossible to completely exclude interactions with other drugs.
Desloratadine does not inhibit CYP3A4 in vivo
, and
in vitro
have demonstrated that the drug does not inhibit CYP2D6 and is neither a substrate nor an inhibitor of P-glycoprotein.
Vivedennya.
A further study of a single dose of desloratadine at a dose of 7.5 mg orally (fatty, high-calorie food) does not affect the pharmacokinetics of desloratadine. It was also found that grapefruit juice also does not affect the pharmacokinetics of desloratadine.
Indications
Desloratadine is indicated for adults and children over 12 years of age to relieve symptoms associated with:
- allergic rhinitis (div. section “Pharmacological authorities”);
- kropivyanka (div. section “Pharmacological authorities”).
Contraindications
Increased sensitivity to active speech or to any of the related speech drugs or to loratadine.
Interactions with other medicinal drugs and other types of interactions
In clinical studies of desloratadine tablets with one-hour infusion of erythromycin or ketoconazole, no clinically significant interactions were observed.
According to clinical and pharmacological studies, when the drug was infused for one hour with alcohol, there was no increase in the negative effect of ethanol on psychomotor function.
However, during the post-acute period, episodes of alcohol intolerance and alcohol intoxication were avoided during the period of drug administration.
Therefore, you need to be careful when drinking alcohol for one hour during treatment with desloratadine.
Features of stastosuvannya
In patients with high-stage nitric deficiency, desloratadine should be taken under the supervision of a physician.
Desloratadine should be used with caution in patients with seizure disorders, medical or family history, especially in young children, who are more susceptible to the development of new seizures when treated with desloratadine. The doctor may consider taking a course of desloratadine in patients who are at risk of being attacked by the court during the hour of treatment.
Desloratadine eliminates lactose. Patients with rare episodes of galactose intolerance, Lapp lactose deficiency and glucose-galactose malabsorption are not required to take this medication.
Directions for use and doses
Administer orally, regardless of consumption.
For older children over 12 years of age: it is recommended to take 1 tablet 1 time per day, regardless of the intake, to relieve symptoms associated with allergic rhinitis (including intermittent and persistent allergies ichny rhinitis) and kropiv'yanka.
Therapy of intermittent allergic rhinitis (presence of symptoms less than 4 days per day or less than 4 days) must be carried out according to the history: register after the symptoms develop and renew after repeat their guilt.
In case of persistent allergic rhinitis (presence of symptoms for more than 4 days per week or more than 4 days), it is necessary to continue to treat the entire period of contact with the allergen.
Children.
It is necessary to combine clinical data on the effectiveness of desloratadine infusion in 12 to 17-day doses (section “Adverse reactions”).
There is no established data on the effectiveness and safety of desloratadine administration in children under 12 years of age.
In clinical studies of indications including allergic rhinitis and chronic idiopathic urticaria, there were no significant effects on desloratadine in patients who took the recommended dose of 5 mg per dose, reported by 3% more often, less often in patients treated with placebo.
The most commonly reported side effects compared with placebo were increased fatigue (1.2%), dry mouth (0.8%) and headache (0.6%).
Children.
In clinical studies involving 578 patients from 12 to 17 years of age, the most common side effect was headache, occurring in 5.9% of patients, as They took desloratadine, and in 6.9% of patients they took placebo.
Other adverse reactions that have been observed during the postnatal period with unknown frequency: prolonged QT interval, arrhythmia and bradycardia.
A summary table of the frequency of adverse reactions.
The frequency is indicated as very often (≥1/10), often (≥1/100,
Source: https://mypharmacy.com.ua/Allergozan/instruction/65566/
Immunotherapy of allergic reactions
At the moment, immunotherapy is the most effective method of treating allergies; it can not only significantly reduce sensitization to the allergen, but also prevent the development of more acute conditions (rhinitis, bronchial asthma). The advantages of allergen-specific immunotherapy include:
- No allergy symptoms.
- No need to take antihistamines.
- Reducing the likelihood of developing allergies.
- Reducing the likelihood of developing acute respiratory tract diseases.
Immunotherapy is based on the use of allergens that cause sensitization in a particular person. With their help, a vaccine is prepared that allows the body to develop tolerance to the allergen.
The only drawback of specific immunotherapy is its duration - from 3 to 5 years. During this time, the body is exposed to small doses of the allergen, gradually increasing the dose so that the person's immune system does not react to it. Immunotherapy is not recommended for pregnant and lactating women; if pregnancy was detected at the first stage of treatment, it is necessary to urgently stop using the drug.
