All about the drug Dexamethasone for allergies and more

How does Dexamethasone work?

For urticaria, taking Dexamethasone is necessary to avoid an acute reaction and prevent anaphylactic shock. The effect of the drug for urticaria is based on improving liver functionality. Thanks to Dexamethasone, the organ begins to quickly remove harmful toxins from the body and cleanses the blood of allergens. The allergy provoked by external factors disappears, the rash goes away.

In the body of a person with urticaria, Dexamethasone has the following effects:

• relieves skin redness;
• eliminates itching;
• improves skin tone;
• eliminates minor rashes;
• rids the body of allergens;
• strengthens local immunity.

As a result, the acute allergic reaction is eliminated. It is necessary to constantly monitor the well-being and condition of the person who has developed an allergy. This will avoid complications of urticaria and prevent its exacerbation.

The drug is produced in ampoules, eye drops, and tablets. For urticaria, Dexamethasone in ampoules and tablets is taken only as prescribed by a doctor. For anaphylactic shock, intravenous injection of Dexamethasone is performed. Also, in critical condition, an ambulance is called. It is possible to treat urticaria with Prednisolone.

Adverse reactions

In isolated cases it is possible:

• headache;
• visual impairment;
• development of liver failure;
• insomnia;
• convulsions;
• neurological disorders.

If adverse reactions occur, you should consult your doctor about further use of Dexamethasone for urticaria. It is possible that the doctor will stop this medication and prescribe another one.

Sources:

Vidal : https://www.vidal.ru/drugs/dexamethasone__36873 GRLS : https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGu >

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Application

Dexamethasone for urticaria can be taken in tablets or given as injections . The dosage of Dexamethasone for urticaria is calculated and prescribed by the doctor individually. If the doctor has prescribed a small dose of the drug for urticaria, then it must be taken once in the morning. If you feel better and the swelling is relieved, it is better to reduce the dose of Dexamethasone.

In severe cases of urticaria, the dosage of the drug may be increased. However, the norm of 5 mg of Dexamethasone should not be exceeded. It is best to discuss the use of Dexamethasone for urticaria with your doctor. In severe cases, it is necessary to increase the dose of the medicine. After the symptoms of urticaria disappear, it is advisable to take Dexamethasone for a few more days to prevent the recurrence of urticaria.

It is better to divide the intake of a large daily dose into several times. It is necessary to take the drug after meals so that the medication does not irritate the gastric mucosa and does not have a negative effect. For young children, Dexamethasone is prescribed only in particularly severe cases, 250 mg/2 kg of the child’s weight.

Dexamethasone injection solution is often used for urticaria . It can be administered intravenously by drip, jet, or intramuscular injection. Intravenous administration of the drug ensures rapid action of the drug. The dosage in the treatment of urticaria is selected by the doctor individually. It should not exceed 80 mg of the drug for symptoms of urticaria.

When anaphylactic shock develops, an adult and a child are prescribed 20 mg of the drug. The dosage should be adjusted by a doctor. The injection is given once. The injection helps to quickly relieve suffocation and has a prolonged effect against urticaria. Then the patient is given a long-term daily infusion at the rate of 3 mg per 1 kg of weight. A single injection is performed intravenously for acute dermatitis in the same dose calculation.

Interaction

When using the drug, it is necessary to take into account some facts about the interaction of dexamethasone phosphate with other substances:

1. A negative effect occurs when Dexamethasone is used simultaneously with antipsychotic and anticholinergic drugs. In the first case, cataracts develop, in the second, glaucoma.
2. The active substance significantly reduces the concentration of insulin-based drugs. It is not advisable to take the drug together with hypoglycemic dosage forms.
3. Acne and hirsutism occur when taken together with estrogenic, androgenic, anabolic-steroid drugs, as well as hormonal contraceptives.
4. Diuretics taken together with glucocorticosteroids contribute to the rapid elimination of beneficial substances.
5. Non-steroidal anti-inflammatory drugs are incompatible with hormonal drugs, as the risk of ulcers and erosions in the gastrointestinal tract increases.
6. Dexamethasone weakens the anticoagulant effect, so it is not advisable to use the corresponding drugs together.
7. It is not recommended to combine a corticosteroid with cardiac glycosides, as the tolerability of the latter worsens.
8. The level of exposure to dexamethasone phosphate is reduced when taken simultaneously with carbamazepine, aminoglutemimmide, ephedrine, barbiturates, phenytoin, and rifampicin.
9. The effect of imatinib and praziquantel is reduced when used together with dexamethasone.
10. Itraconazole enhances the effectiveness of the hormonal drug.
11. Methotrexate with Dexamethasone increases hepatotoxicity.

Contraindications

You should not always resort to Dexamethasone for urticaria.

The medicine is contraindicated in:

• exacerbation of psychosis;
• diverticulitis;
• nephrourolithiasis;
• polio;
• gastritis;
• esophagitis;
• ulcer;
• liver failure.

Dexamethasone should be used with caution in the treatment of urticaria if the patient has heart failure and heart disease. Also, the medicine is not used for glaucoma, endocrine pathologies, or postoperative complications.

Special instructions:

• Treatment of urticaria with Dexamethasone should be supervised by your doctor. Dexamethasone has a pronounced therapeutic effect for urticaria, but it should only be prescribed by a specialist;
• The hormone Dexamethasone is used with extreme caution in the treatment of children. In some situations, side effects may occur that require immediate dosage reduction or discontinuation of Dexamethasone for urticaria;
• Taking Dexamethasone tablets for urticaria is not compatible with drinking alcohol. The alcohol it contains inhibits the action of the active drug substance and can cause unwanted reactions from the body. Alcohol can worsen the symptoms of hives and prevent the injected medicine from adequately treating the illness.

Manufacturer

Dexamethasone is produced in different countries:

1. Russia: HFC Akrikhin, Bryntsalov, Vector, Wicher-Pharm, Vostok, DalKhimPharm.
2. Germany: Weimer Pharma GmbH, Bayer AG.
3. Poland: Warsaw Pharmaceutical.
4. Thailand: General Drag House.

Dexamethasone is a medication that must be used with caution. To do this, before admission, the patient must undergo a comprehensive examination to identify diseases and conditions included in the list of contraindications. During therapy, the patient is required to visit the attending physician to monitor the state of health and the dynamics of treatment. These are prerequisites for achieving a successful result.

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Allergies in children

Depending on the symptoms, doctors may prescribe Dexamethasone intramuscularly for children with allergies, in the form of eye drops or in the form of inhalations. This drug is usually not given intravenously to babies.

The basis for choosing this medicine in the form of drops for children over 6 years old may be processes such as:

• inflammation of the conjunctiva of the eyes (conjunctivitis);
• inflammation leading to clouding of the cornea (keratitis);
• inflammatory processes in the tissues of the eyelid (blepharitis);
• inflammation of the optic nerve (neuritis).

The use of the drug "Dexamethasone" in the treatment of allergies and after surgery helps to eliminate an unwanted process in the body. Therefore, it is often prescribed in treatment regimens for various pathologies.

In the form of inhalations, Dexamethasone for allergies in children is used in combination with saline solution in a dosage of 1:6 (1 ml of medication to 6 ml of Sodium chloride). The solution is prepared immediately before the procedure and applied in an amount of 3-4 ml. This allows you to achieve the optimal result of relieving bronchospasms in asthmatic manifestations and eliminating the possibility of burns to the nasopharyngeal mucosa. Treatment of allergies with Dexamethasone using a nebulizer usually resolves within 7 days.

The most effective drugs

What should you take to treat urticaria? Let's look at the best and most common drugs:

Gistan-N.

An ointment based on glucocorticosteroids, which slows down the development of an allergic reaction and inflammation, prevents the development of bacterial and fungal infections.

Contraindications: syphilis, tuberculosis, childhood, pregnancy and lactation (not always), acne, dermatitis.

In case of overdose, adrenal insufficiency and other diseases of the endocrine system occur.
Side effects - itching, dermatitis, skin atrophy. Price in Russia – 150-200 rubles, in Ukraine – 50-100 UAH; Ceterizine (common name Zirtec) is one of the popular antihistamines, included in the list of vital ones.
This remedy eliminates the very cause of allergies, replacing histamine. In addition to urticaria, it is also effective against other forms of allergies, such as asthma.

In case of an overdose, drowsiness, irritability, and urinary retention occur.

Contraindications: kidney and liver diseases, pregnancy and lactation.
It costs about 800-1000 rubles in Russia and about 200-300 UAH. in Ukraine; Montelukast is an antileukotriene drug.
Often prescribed to treat urticaria and asthma.

Price about 1000 rubles. (about 300-400 UAH). A very effective drug, but with a serious drawback - many side effects from the central nervous system and digestive system.

Possible vomiting, nausea, headache, and in case of overdose – hallucinations and loss of orientation in space.
Contraindicated for pregnant and lactating women; Dapsone (4,4′-Sulfonylbis) is a drug that is prescribed if a bacterial or fungal infection is associated with hives.
Common and potent, this remedy is contraindicated for anemia and liver disease, and during pregnancy and lactation it is used only in extreme cases and under strict supervision.

Side effects - mood changes, nausea, vomiting, dermatitis; in case of overdose, serious liver damage and cyanosis (cyanosis) are possible. Dapsone is an expensive drug, its price in Russia is 5,000 rubles or more, in Ukraine – from 2,000 UAH.

Dosage

Tablet form (take orally, without chewing, wash down):

Eye drops: use 3 times a day, instilling 1-2 drops.

the ointment 1-3 times a day, in a thin layer to damaged areas of the skin. On limited lesions, occlusive dressings are applied to improve the effect.

Other drugs

1. Antihistamines are a large group of medications that have been known since the 1930s. They suppress the action of histamine, a substance responsible for the development of allergies and inflammation. Thus, antihistamines reduce swelling, redness, prevent fever from developing and indirectly prevent infection.

They are divided into 4 generations, each subsequent one more perfect and safe than the previous one:

First-generation drugs are distinguished not only by high activity, but also by strong side effects, especially from the central nervous system.

These include Diphenhydramine, Diazolin, Suprastin, Tavegil. For urticaria, Diazolin is most often prescribed.

All of the drugs listed have a significant disadvantage: they cause drowsiness and inhibited reactions.
This makes them dangerous in cases where the patient needs to operate vehicles, machinery, etc.; the second generation (LoraGexal, Lomilan, Clarotadine, etc.) was developed to reduce the effect on the central nervous system.
Also, these medications began to have a longer lasting effect (up to a day).

The disadvantages include the fact that many of them cause side effects from the gastrointestinal tract and liver, and also cause drowsiness;
the third generation of antihistamines (Telfast, Gistaman and Trexil) are even safer drugs that show virtually no sedative effect.
There are practically no downsides to using them, except for the possibility of mild dizziness and nausea;

• fourth generation – the most modern drugs. These include Levocetirizine, NeoClaritin, etc. Even more effective and safe, they act for a long time, so taking 1-2 times a day is enough.

This drug blocks the release of histamine and improves liver function. It prevents the development of Quincke's edema and shock.

The drug is considered quite dangerous; it is not recommended for use for gastritis, glaucoma, heart disease, liver disease, ulcers and a number of other diseases.

When using, read the instructions very carefully.
Taking Dexamethasone for urticaria can be called a “last resort”. Prednisolone prevents the development of the inflammatory reaction.
On the one hand, the drug prevents leukocytes from moving to the area of ​​inflammation, on the other hand, it reduces capillary permeability. That is, it eliminates the effects of histamine.

The disadvantages include a large number of side effects, including increased blood clotting (dangerous in case of thrombosis), mental disorders, and cataracts.
Calcium gluconate.
This substance reduces the permeability of cell membranes (thanks to calcium). Thus, the allergen simply stops working.

The drug is cheap and very safe (side effects are rare and only from the gastrointestinal tract - nausea, vomiting, diarrhea).

However, the course of treatment usually lasts 1-2 weeks, so the remedy is not suitable for emergency use.
Enterosgel removes toxins and allergens from the body.
Prescribed for urticaria, incl. as an aid.

An important plus is that it is safe, the only side effects are constipation.

The downside is the long treatment period (two weeks). Activated carbon acts in the same way as the previous drug: it removes harmful substances from the body.

There are no disadvantages at all, the advantages are efficiency, reliability, harmlessness to the body.

Before use, it is advisable to chew the charcoal tablets to increase the surface area. Coal is indispensable if urticaria is accompanied by diarrhea (this often happens).

In this case, the drug helps stop diarrhea and prevents the loss of large amounts of water.
thiosulfate is both a remedy for toxic poisoning and an antihistamine.
An important advantage is that it is non-toxic, although it may cause allergic reactions.

In addition, it is able to normalize the functioning of the gastrointestinal tract through its effect on the smooth muscles of the intestine.

In case of overdose, it can cause a decrease in blood volume, and this leads to a high load on the kidneys, but if the dose is observed, this phenomenon is not observed.

Thiosulfan has an unpleasant taste, so it is often used as an injection solution. If the patient takes it orally, it is better to swallow it quickly with sugar and lemon.

Also, during treatment with this remedy, it is advisable to exclude dairy and meat products from the diet.
Diprospan is an antiallergic drug with many side effects.
Can cause depression, insomnia, neurosis, obesity, osteoporosis, worsening diabetes, etc.

At the same time, it acts quickly and has a double effect against urticaria: it prevents the development of an allergic reaction and does not allow inflammation to develop.
Cetrin.
A good drug, effective for both acute and chronic forms of the disease.

Available in tablets, excreted in the urine (therefore, you need to be careful if you have kidney disease).

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A single dose per day is sufficient.
Overdose may cause migraines, flatulence, drowsiness, and dry mouth. Erius relieves inflammation, itching, and swelling well.
Used in acute cases when immediate help is required. Blocks the production of histamine and other substances responsible for the development of allergies.

The effect occurs 30 minutes after administration.
The big advantage of the drug is its safety. Minus - sometimes side effects may develop (headache, muscle pain, tachycardia). Smecta.
Like coal, it is a mineral preparation that absorbs harmful substances: toxins, allergens, etc. It is effective against diarrhea; in case of overdose, it can cause constipation.

The advantage is that the drug is completely safe: it is not absorbed into the blood and does not in any way affect processes occurring outside the gastrointestinal tract.
It is excreted together in feces. This is also the disadvantage: Smecta will help with diarrhea, but with other manifestations of urticaria it is powerless. Tsindol.
A good product for external use. Contains zinc oxide, which relieves inflammation and dries.

In addition to allergies, it is used for a number of other skin diseases. Effectively eliminates pathogenic bacteria and fungi, preventing the development of infection.

Tsindol is cheap, effective and safe. A significant drawback is that zinc oxide does not help eliminate the cause of allergies, but only fights the consequences.

General principles

Since urticaria is a type of allergy, there are two main directions in its treatment:

• isolation of the patient from triggers (factors that initiate the allergic process);
• combating an already developed disease (taking antihistamines, treating concomitant infections, eliminating individual symptoms, etc.).

Let's consider the main methods that are used to treat urticaria, in the form of a table:

The methods listed above are effective for both prevention and treatment of an already established disease.
They can and should be used in parallel with taking medications. At the same time, it is very important to adjust the diet so as to exclude dangerous foods: red, orange vegetables and fruits, however, you should not switch to meat.
The diet should consist mainly of plant and dairy foods.

Only if you isolate yourself from allergens and follow the correct diet can you expect that drug treatment will bring results. Otherwise, the patient will constantly provoke the disease again.

How is urticaria treated with drugs: how can adults quickly recover from it?

Urticaria in adults is a common and dangerous disease of an allergic nature. It received its name for the similarity of the external manifestation - a red rash on the skin and mucous membranes - with a nettle burn.

In addition to the characteristic appearance of the affected area, urticaria can manifest itself in the form of itching, fever, and gastrointestinal upset.

Fortunately, urticaria can be treated, and today there are hundreds of drugs that can relieve the disease.

In this article we will describe in detail how urticaria is treated with drugs. How to quickly recover from it? What can you drink and what is better to apply for hives? Reading the article.