Recently, more and more people have begun to complain of an allergic reaction. Some people may have seasonal or chronic allergies, and some complain of itching or rashes due to taking pharmacological medications. There are many reasons that cause allergies. But regardless of them, most people take Diazolin to block allergic processes. Indications for the use of the drug, features of its dosage, distinctive features, contraindications - we will cover all these issues in our article.
Indications for use
Indications for the use of the drug for allergies may include the following manifestations:
- development of urticaria;
- active phase of allergic conjunctivitis;
- seasonal or chronic occurrence of rhinitis;
- dermatoses accompanied by eczematous skin rashes;
- neurodermatitis;
- the appearance of a skin reaction as a result of an insect bite;
- serum sickness;
- hay fever, hay fever;
- dermatitis of varying severity;
- angioedema;
- liver and kidney failure (the drug is used with caution, as there may be a need to adjust the dose, as well as time intervals);
- sometimes the drug can be used in complex therapy to relieve a bronchial attack;
- It must be taken into account that taking diazolin may be accompanied by an increase in blood pressure, so it should be used with caution in hypertensive patients.
In relieving allergy symptoms, Diazolin stands out noticeably among other first-generation antihistamines (diphenhydramine). It gently crosses the blood-brain barrier, which minimizes side effects.
why allergies occur
Diazolin is an antihistamine used in the treatment of various allergic diseases. Active ingredient: Mebhydrolin.
Histamine H1 receptor blocker, ethylenediamine derivative. It has antiallergic, antipruritic, antiexudative, and also mild sedative effects.
Has m-anticholinergic properties.
Blocks histamine H1 receptors, reduces the tone of smooth muscles (bronchi, gastrointestinal tract, uterus), reduces capillary permeability and the development of edema, and prevents itching.
Diazolin is available in the form of tablets for oral administration. The active ingredient of the drug is mebhydroline napadisylate 100 mg in an adult dosage and 50 mg in a pediatric dosage.
Unlike many antihistamines, it does not cause drowsiness.
The therapeutic effect develops 15 minutes after taking the tablet and lasts up to 48 hours.
What do Diazolin tablets help with?
According to the instructions, the drug is prescribed in the following cases:
- allergic skin rashes;
- itching of the skin as a reaction to insect bites;
- hay fever;
- allergic conjunctivitis;
- allergic rhinitis;
- hives;
- treatment of rashes that occur while taking certain medications;
- food allergies in adults and children.
Contraindications
The drug is not recommended for use in:
- individual intolerance of the patient;
- in inflammatory processes occurring in the gastrointestinal tract (peptic ulcer, gastritis, esopharyngitis, etc.), as it can enhance stimulation of gastric secretions;
- It is not recommended to take Diazolin if the patient has a history of epileptic seizures;
- angle-closure glaucoma is a contraindication for the use of the drug;
- It is forbidden to take antihistamines for cardiovascular failure with heart rhythm disturbances;
- prostate enlargement;
- children under 3 years of age;
- with caution during pregnancy and breastfeeding;
- individual intolerance to the components of the drug;
- It is strictly forbidden to take tablets with alcohol.
It should be noted that this drug has a sedative effect, so when prescribing it to relieve allergies, it is necessary to take into account the patient’s profession. In cases where work involves increased concentration, taking this drug is prohibited.
pharmachologic effect
The active ingredient of Diazolin is Mebhydrolin. H1-histamine receptor blocker. Reduces the development of edema and has antipruritic, antiallergic and antiexudative effects.
Unlike first generation antihistamines, Diazolin does not have a strong sedative and hypnotic effect and weakens the effect of histamine on the smooth muscles of the uterus, bronchi and intestines. The maximum effect of the drug is observed after 1-2 hours and can last up to 2 days.
Side effects
Like any medicine, diazolin has side effects:
Digestive system
due to stimulation of the production of hydrochloric acid as a result of the influence of the drug, dyspeptic disorders may occur, expressed by vomiting;
- attacks of nausea;
- loose stools (or, conversely, constipation);
- epigastric pain.
From the central nervous system
- sudden dizziness;
- paresthesia;
- with allergies, the patient is inhibited;
- rapid onset of fatigue;
- optic nerve disorder;
Hematopoiesis
- very rarely granulocytopenia and agranulocytosis may occur.
Other
- dry mouth;
- frequent urination.
In childhood, the use of the drug can sometimes be accompanied by symptoms uncharacteristic for adult patients: tremor, irritability, tearfulness, increased excitability and sleep disturbances.
Analogs
Diazolin cannot be considered one of the newest and most modern anti-allergy drugs. It is a first generation drug, which includes other drugs with similar characteristics:
- Suprastin;
- Pipolfen;
- Diphenhydramine;
- Tavegil.
However, it must be remembered that any medicinal solutions and tablets in this group still have some differences, despite the same pharmacological series.
Recently, many medications have appeared that are more effective and safe. However, the drug has certain advantages: the price of the drug is affordable for all categories of patients. In addition, many years of experience in use have proven its reliability and proven ability in the fight against allergic manifestations.
Instructions for use
The pharmaceutical drug must be consumed with food or immediately after taking it.
Release form: the drug can be in the form of dragees or tablets of 50-100 mg.
Adult patients are prescribed from 50 to 200 mg at a time, at least three times a day, depending on the severity of the symptoms of the disease.
In children, starting from 3 years, 25 to 50 mg is recommended. Diazolin 1-3 times during the day.
The recommended dose of diazolin is 100 to 200 mg per day. Your doctor may increase this dosage to 600 mg.
The duration of the treatment course is selected individually in accordance with the severity of the disease and its course.
Diazolin is ineffective for angioedema and anaphylactic shock, since it does not have a rapid effect, and these conditions require emergency medical intervention.
In addition, it is important to consider that tablets can enhance the activity of sedative medications that have a hypnotic and sedative effect.
It is worth special mentioning the use of diazolin during pregnancy, as well as during breastfeeding. During these conditions, the patient may be prescribed antihistamines and, in particular, diazolin, if allergic symptoms pose a threat to the patient’s life. However, the use of the drug is permitted only under the supervision of the attending physician.
When prescribing diazolin during this crucial period for a woman, the attending physician must exercise maximum caution, having previously familiarized himself with the course of pregnancy.
As a rule, pregnant women should take 1 tablet per day with food, unless otherwise prescribed by a doctor. It is important to consider that these tablets have the most prolonged (long-lasting) effect among drugs in this group. This is an important factor when choosing a drug to relieve allergies during pregnancy.
Any drug treatment should be selected only by a doctor, therefore independent withdrawal or replacement of diazolin is strictly prohibited! This can lead to serious health complications.
How to take Diazolin for allergies?
It is advisable for any allergy sufferer to have antihistamines in their medicine cabinet that stop the effect of the irritant and eliminate rashes, swelling, and itching. A proven allergy remedy, sold in pharmacies for a long time, is Diazolin. It belongs to the group of first generation drugs.
Operating principle
Diazolin is a histamine receptor blocker. It helps reduce the toxic effect of antigens. The active ingredient is mebhydrolin.
The product reduces swelling and redness of the mucous membranes, relieves increased vascular permeability, weakens the effect of histamine on the bronchi, intestines and uterus, and prevents a strong decrease in pressure.
It makes breathing easier, reduces a runny nose, removes rashes, itching, eliminates swelling and irritation of the eyelids, and lacrimation. Has weak anesthetic properties.
The drug, absorbed from the intestines, quickly penetrates the body tissues. It begins to act after a quarter of an hour, maximum effectiveness can be expected after 1-2 hours. The effect of the medication lasts up to 2 days. It does not cause severe lethargy and drowsiness, since it practically does not have the ability to penetrate the membrane of nerve cells.
When can the product be used?
The drug is most effective against allergies caused by food and drugs.
The main indications are:
- developing urticaria;
- allergic conjunctivitis in the active phase;
- itchy dermatoses;
- dermatoses with painful rash;
- hay fever;
- rhinitis (chronic or seasonal);
- bronchial spasms;
- allergic reaction to insect bites;
- serum sickness;
- impaired functioning of the kidneys and liver (should be used with caution, individual dosage selection is required).
Diazolin can also be used for preventive purposes. The frequency of administration and dosage is determined by the doctor.
Release form
Diazolin is produced in 3 forms:
- Tablets of 50 and 100 mg in plates of 10 pieces (packs of 10, 20 tablets).
- Dragees 50 and 100 mg (similar packaging).
- A powder substance with a greenish or creamy tint and a crystalline structure. Packaged in two-layer polyethylene bags of 1, 5, 10 kg.
The drug is available in pharmacies without a prescription. A dosage of 50 mg is intended for children, 100 mg for adults. The powder is rarely used due to the inconvenience of use (large volumes, difficult to measure). Dragee is mainly recommended for children, as it contains natural ingredients and has a pleasant taste.
Pregnancy and breastfeeding
The drug is not recommended for pregnant women. However, the question of its prescription must be decided by the doctor. If the potential danger for a woman with developed allergies is higher than the harm from the product, then use starting from the 2nd trimester is possible. It is carried out under strict medical supervision.
However, if possible, it is better to prefer more modern and safe drugs that have fewer undesirable consequences. During lactation, taking Diazolin is also allowed, if there are no other options, as prescribed by a specialist.
But breastfeeding will need to be stopped.
Rules for taking Diazolin
Tablets, pills or powder are taken with meals or a few minutes later. No chewing required. You need to drink the product with water.
For adults with allergies, it is recommended to take Diazolin in a dosage of 50 to 200 mg three times a day. Daily dose – no more than 600 mg . The medication is prescribed in similar quantities to adolescents over 12 years of age.
Children 3-5 years old - 50 mg 1-2 times a day, 5-10 years old - 50 mg three times a day, 10-12 years old - 50 mg 3-4 times a day.
The dosage and duration of the therapeutic course is determined by the doctor. The severity of the disease and its course are taken into account.
Storage conditions
Diazolin powder, dragees and tablets should be stored indoors at room temperature. It is important to prevent access to light, so the plates should be kept in a cardboard box. The shelf life of solid forms is up to 3.5 years, powder – up to 5 years.
Please note that the sweet, candy taste of the medicine may attract small children. Therefore, we need to hide the packaging better.
Price
The medicine is available and inexpensive. The average cost of a package of N10 (50 mg) is from 25 to 70 rubles, a package of N10 (100 mg) is from 55 to 90 rubles, a package of N20 (100 mg) is 100-120 rubles. The price can vary significantly depending on who the manufacturer is. Markups of a particular pharmacy chain also matter.
Overdose
Sometimes, if a drug is used incorrectly to relieve allergy symptoms, an overdose is observed, manifested by the following symptoms:
- throbbing headache radiating to the temporal region;
- sudden dizziness accompanied by loss of consciousness;
- complete inhibition of the patient, up to stupor;
- altered mental consciousness;
- In addition, tablets and pills taken in excess of the norm can impair coordination of movements.
First aid for a drug overdose consists of urgent gastric lavage to remove toxic substances from the body. Further treatment of allergies is carried out in accordance with the symptoms.
Pharmacodynamics and pharmacokinetics
Mebhydrolin contained in this drug is an antihistamine that blocks histamine H1 receptors. It significantly reduces the spasmogenic effect of histamine on the smooth muscles of the intestines and bronchi. It also affects vascular permeability. If we compare this drug with first-generation antihistamines, such as suprastin or diphenhydramine, then its sedative and hypnotic effects are much less pronounced. Diazolin also has anesthetic properties, but they are weak.
Absorption of the drug occurs very quickly, and after 15-30 minutes it begins to act. The maximum effect in patients is observed after 1-2 hours, while its duration is up to two days. It is excreted from the body through the kidneys.
Patient reviews
Since diazolin tablets and dragees are in great demand due to their affordability, many patients would like to receive much more information about their pharmacological action. Therefore, numerous Internet forums and specialized medical sites are studied with special care.
It is important to note that many mothers speak positively about this drug. It tastes sweet, comes in a nice package, and children take it with pleasure. In addition, the long-term effect allows you to reduce the use of the drug for allergies to once a day. A distinctive property of the medicine from drugs of this series is the absence of hypnotic effects.
There are also negative reviews: for patients with a complicated course of the disease, it is ineffective. In addition, in some patients it causes dyspeptic and hyperthermic symptoms.
Diazolin is widely used in the treatment of allergic manifestations of various types and, accordingly, there are a great many reviews from people using this drug. To choose or not to choose is an individual matter for each patient. It is quite natural that the attending physician, who is able to adequately assess all the advantages and disadvantages of using this drug, should take part in the choice.
Directions for use and dosage
For the drug to be beneficial, you must take it according to the following regimen:
- The daily dose for children under 2 years of age is 50-100 mg; 2-5 years – 50-150 mg; 5-10 years – 100-200 mg. Children over 10 years old: 100-300 mg. It is recommended to divide the daily dosage into 2-3 doses.
- Do not chew the tablet, wash it down with water. An exception is made for small children: they are allowed to crush the tablet before use and dilute it with water.
- The drug is taken after meals.
- The duration of treatment is prescribed by the doctor. Usually it does not exceed ten days.
Can it be given for chickenpox or allergies?
The product can be used for chickenpox and allergies, as the active ingredients relieve itching, redness, and rash. Chickenpox goes away much faster . Allergies can also be eliminated with this remedy. The dosage of the medication is no different. It is taken according to the standard scheme.
