ZODAK or ZODAK EXPRESS: which is better and what is the difference (differences in composition, doctors)

Zodak Express or Zodak are drugs that have an antihistamine effect. Eliminates clinical manifestations of an allergic reaction in adults and children. They do not have a calming effect on the body, so use at any time of the day is acceptable. They are used to eliminate symptoms of rhinitis of allergic origin, atopic dermatitis, and inflammation of the bronchi.

Zodak Express or Zodak are drugs that have an antihistamine effect.

Differences between Zodak and Zodak Express

They differ in their active ingredients. Zodak consists of cetirizine, Zodak Express - of levocetirizine. Cetirizine is an organic compound that has the same content of R- and L-forms in solution, of which only the R-form is in the active state.

Levocetirizine contains only derivatives of the R-form of cetirizine constituents, which do not contain L-forms. Therefore, Zodak Express has a great therapeutic effect.

Release form Zodak Express - tablets, Zodak is available in the form of drops, syrup, tablets, more convenient to use, because syrup or drops can be given to children who cannot swallow tablets.

What is the difference between Zodak and Zodak Express?

A drug called Zodak is presented on the pharmaceutical market in the form of drops and tablets - the instructions for use say that the product is effective against allergies. The advantage of the medication is that it has an antisedative effect; when you take it, you don’t feel sleepy. The drug helps to actively combat allergic manifestations such as itching and rashes.

What is Zodak

The 2nd generation drug – Zodak has a prolonged effect, due to which the duration of action of the main component increases.

The medication shown in the photo eliminates allergy symptoms due to the active substance - a selective blocker of peripheral H1 receptors. Indicated for use during exacerbation of seasonal allergies, as well as chronic diseases of this type.

Even if you take the drug for a long time, there will be no problems with the central nervous system (drowsiness or depression).

Composition of the Zodak

The main active ingredient, cetirizine dihydrochloride, acts against the body’s negative reaction to irritants in the early (histamine-dependent) and late cellular phase.

Under the influence of the substance, histamines undergo a process of release from various cells (mast cells, basophils, etc.).

Zodak - instructions for use describe the composition of different release forms - the drug is popular, here is its composition:

Release formAdditional components

Syrup
  • propylparaben;
  • acetic acid;
  • methylparaben;
  • propylene glycol;
  • banana flavoring;
  • sodium acetate;
  • glycerol 85%;
  • sodium saccharin;
  • sorbitol syrup.
Pills
  • dimethicone emulsion;
  • corn starch;
  • macrogol;
  • lactose monohydrate;
  • magnesium stearate;
  • lactose monohydrate;
  • talc;
  • povidone;
  • titanium dioxide;
  • hydroxypropyl methylcellulose.
Drops
  • propylene glycol;
  • propylparaben;
  • purified water;
  • methylparaben;
  • acetic acid;
  • glycerol 85%;
  • sodium saccharin;
  • sodium acetate.

Release form

Zodak is available in 3 different types of the drug: tablets, drops, syrup. Zodak drops or syrup form are more suitable for children. The latter option has a banana smell and taste, which makes its intake pleasant and healthy.

Adults can choose Zodak tablets, which are more practical: a person, knowing in advance that he may be exposed to an irritant, can take the medicine in any environment.

Below is a table of release forms and their features:

Release form Quantity External characteristics

Syrup100 ml, one bottle (5 mg/ml).The syrup appears transparent, slightly yellow in color.
Pills5 each; 10; thirty; 60; 90 pcs., blister pack (10 mg). Biconvex tablets in a white shell of an oblong shape. There is a risk on one side.
Drops20 ml in a bottle (10 mg per 1 ml).With a pale yellow tint or without color.

Zodak - indications for use

The drug is effective against seasonal allergies, in the treatment of diseases with an established diagnosis, including manifestations of allergic reactions.

The drug is taken at the first symptoms associated with the body's response to irritants of various origins.

The doctor prescribes Zodak for symptomatic therapy, for diseases such as conjunctivitis, year-round allergic rhinitis. List of symptoms and diseases that Zodak helps with:

  • urticaria, normal or with fever (chronic idiopathic urticaria);
  • swelling of the mucous membrane;
  • itching;
  • chronic or seasonal allergies;
  • sneezing;
  • allergy to flowering plants (hay fever);
  • cough;
  • itchy dermatoses of allergic origin;
  • Quincke's edema.

For children

Children over 6 years of age are allowed to take antiallergic drugs in the form of tablets. Taking such a remedy as Zodak is strictly prohibited for children under one year of age. Information about the prohibition for newborns is indicated as a contraindication to the medication.

If there is an urgent need to take a drug with a similar effect, the doctor prescribes the child an analogue with a similar active ingredient, which is approved for children under one year of age.

A child after one year can take drops or syrup in the dosages indicated in the instructions or prescribed by a doctor.

For adults

For allergic symptoms, an allergist may prescribe Zodak for adults. The convenient form of the drug in the form of tablets does not cause discomfort throughout the day.

You can take 1 tablet with a glass of water anywhere, this will help get rid of food or other allergies. Adult patients should remember that the drug should not be combined with alcoholic beverages.

Zodak does not work after drinking alcohol.

Is Zodak possible during pregnancy?

Zodak should not be taken during pregnancy; the drug is prohibited during lactation and pregnancy.

The antiallergic drug Zodak is an antihistamine, and in the first trimester, taking any drugs with a substance that suppresses the effect of free histamine is prohibited.

After the onset of the second trimester, in severe cases, the doctor may prescribe Zodak. The danger of taking the medication is that any antihistamines have a negative effect on the fetus.

How does Zodak work?

Histamine is a biogenic substance that is involved in the development of reactions to allergens. The active component suppresses the release of histamine due to its property of blocking nerve endings (H1 receptors).

Zodak is most effective at the initial stage of interaction with the allergen. The medicine reduces the permeability of capillaries (small blood vessels), which protects against the development of bronchospasm.

Doctors advise taking Zodak for allergies in advance, at the first suspicion of penetration of an irritant.

Zodak drops - instructions for use for children

A children's allergist or pediatrician can reliably determine the cause of the child's body's hypersensitivity in response to irritants. The specialist prescribes the medicine in the form of drops in a convenient bottle, which will prevent children from spilling the medicine.

One bottle contains 10 mg of the active substance - cetirizine, under the influence of which the allergy chains are blocked and the symptoms disappear. Zodak's instructions for use state that the medication should be dissolved in water (5 ml) and drunk.

The product has the following effects:

  • antiexudative;
  • decongestant;
  • antipruritic.

How long can a child take Zodak?

The instructions for use say how many days children can take Zodak. Among the general recommendations, we can highlight that you should take the medicine at the same time every day, trying not to miss a dose.

The duration depends on the form of release and the concomitant disease. The instructions for use of the medicine contain a table in which you can find out the course of treatment.

Therapy can last from 5 to 7 days, in some cases up to a year, with breaks between doses.

How to take Zodak drops for children

You can take the product regardless of meals. The required dose of the drug is dissolved in water. Zodak is not used for newborns.

Parents who have experienced allergic reactions in their children after one year are interested in the question of how many drops of Zodak to give to their child: a doctor can answer this.

After reading the information about Zodak drops - instructions for use are available - you can find out that the correct dose and time of taking the drug depends on the age of the child:

  1. From 1 to 2 years: 5 drops twice a day (2.5 mg each).
  2. From 2 to 6 years: 10 drops 1 time (5 mg each) or 5 drops 2 times (2.5 mg each).
  3. From 6 to 12 years: 20 drops per 24 hours (10 mg each) or 10 drops (5 mg each) twice.
  4. Over 12 years: 20 drops (10 mg each), evening.

Zodak - instructions for use for adults

Eating does not affect the absorption of the drug into the body. If the instructions for use say that the product is taken once a day, then it is better in the evening. When taking the drug twice a day, it is consumed at 9 am and 9 pm, at equal intervals.

The medicine in tablet form should not be crushed, but should be drunk with plenty of water. If a dose is missed, it cannot be combined with a new one. The instructions for use of Zodak state that patients with impaired renal and liver function should take a reduced amount.

How to take Zodak for adults

The three forms of the medicine must be taken differently due to the fact that the concentration of the substance in the tablets, syrup or drops is not the same. After administration, the drug begins to act after 20 minutes. After 60 minutes, the highest effect occurs; 0.3% cetirizine is bound to blood proteins.

Zodak's abstract states that the duration of the healing property lasts 24 hours. Due to these features of the drug, when taking it, you must refrain from driving a car and doing things that require concentration.

The instructions for use indicate the following dosage of Zodak for adults:

  • tablets: 1 dose, 1 tablet. (10 mg/day);
  • drops: 1 dose of 20 drops (10 mg);
  • syrup: 1 dose, 2 measuring spoons.

Side effects

Zodak - the instructions for use state that in case of overdose the development of side effects is observed - in most cases it is well tolerated by patients.

Rare side effects are observed, but they are transient. If any of the following signs of overdose occur, you should rinse your stomach, take activated charcoal, and carry out symptomatic therapy.

Instructions for use indicate the following side effects of Zodak:

  • skin itching;
  • hives;
  • angioedema;
  • rash;
  • dyspepsia;
  • problems with the digestive system;
  • dry mouth;
  • sedation or drowsiness;
  • headache;
  • migraine;
  • increased fatigue;
  • excitation;
  • dizziness.

Zodak price

Before buying the drug, you should consult a doctor who will prescribe the dosage according to the instructions. How much does Zodak cost? The price depends on the manufacturer and place of purchase in Moscow or St. Petersburg. You can buy it at a pharmacy kiosk or order it from an online pharmacy with delivery at a reduced cost. Table of approximate prices for an antihistamine against allergies:

Release form and quantityManufacturerPrice, rubles

Drops 0.01/ml 20 mlSanofi, Russia208
Express tablets 0.005 No. 28Sanofi, Russia534
Tablets 10 mg 10 pcs.Zentiva k.s., Czech Republic143
Express tablets 5 mg 28 pcs.Zentiva k.s., Czech Republic515
Syrup 5mg/5ml fl t/s with measuring spoon 100ml/N1Czech Republic, Leciva150

Analogues of Zodak

Substitutes for any drug are divided into 2 types: absolute and relative. The first ones are those that contain cetirizine dihydrochloride. When searching for analogues of Zodak, you should pay attention to the content (dose) of the active component.

Be sure to read the instructions for use. The same components in ointments and tablets do not mean an identical method of use. Relative substitutes are similar to this medicine in their mechanism of action.

Absolute analogues include the following drug names:

  • Letizen;
  • Zyrtec;
  • Parpazin;
  • Cetrin;
  • Allertek;
  • Zintset;
  • Alerza.

Among the relative and cheap analogues are:

  • Nasonex;
  • Tavegil;
  • Avamis;
  • Suprastin;
  • Vibrocil;
  • Galazolin;
  • Nazivin;
  • Tizin.

Advertisement Zodak: Zodak eliminates allergies in 20 minutes

Reviews

Anfisa, 33 years old I have been taking the drug for 5 years for every spring exacerbation. In April, flowering begins, nasal congestion, runny nose and dry cough. To alleviate my condition, I take the medicine according to the instructions (20 drops diluted with water). Many pharmacies sell medications at a discount.

Dmitry, 29 years old Every season poplars and other trees begin to bloom. I experience coughing, sneezing and swollen eyes. Zodak helps remove unpleasant symptoms. I took this drug according to the instructions: 1 tablet per day. The remedy helps in 20 minutes, but for a complete recovery it is worth taking the course.

Attention! The information presented in the article is for informational purposes only. The materials in the article do not encourage self-treatment. Only a qualified doctor can make a diagnosis and give treatment recommendations based on the individual characteristics of a particular patient.

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Source: https://detki.shukshin-net.ru/chem-zodak-otlichaetsja-ot-zodak-jekspress/

Contraindications

Zodak has the following contraindications:

  • sensitivity to the components of the drug, especially to piperazine and its derivatives;
  • renal failure at the last stage and with a chronic course;
  • children under 6 years old;
  • pregnancy period;
  • epileptic seizures;
  • convulsive syndrome;
  • diseases that are accompanied by urinary retention;
  • enlargement of the prostate gland;
  • spinal cord injuries.

During breastfeeding, the drug can be taken only if necessary. Treatment with the drug should be carried out with caution in elderly people.

Zodak Express eliminates the clinical manifestations of an allergic reaction in adults and children.

Zodak Express has the following contraindications:

  • increased sensitivity of the body to the components included in the drug;
  • acute and chronic forms of renal failure;
  • children under 6 years old;
  • lactose intolerance from birth;
  • pregnancy;
  • lactation period;
  • incompatibility with alcoholic beverages;

It should be taken with caution in old age, with diseases associated with urinary retention, chronic damage to liver tissue.

How to take Zodak and Zodak Express

Zodak drops are used in children from 1 year old, tablets - from 6 years old. The drug can be used both before and after meals.

If you miss a dose of the drug, take it as soon as possible, but do not exceed the stated dosage.

Drops for children:

  • children from 1 to 2 years old – 2 times a day in the amount of 5 drops;
  • children from 2 to 6 years old – 5 drops 2 times a day, or 10 drops once in the morning;
  • children from 6 to 12 years old - a dose of 20 drops, can be divided into 2 doses (morning and evening) of 10 drops each, or once in the amount of 20 drops in the morning.

In case of renal failure, the dosage is reduced by half. Use in adult patients and children over 12 years of age - one tablet (5 mg) 1 time per day.

Zodak-Express adults and children over 6 years of age take 1 tablet in an amount of 5 mg, 1 time per day, without chewing, with plenty of liquid.

In elderly patients with impaired renal function and liver failure, dose adjustment by a physician is required.

Instructions for use Zodak for children and adults

For frequent allergy attacks, it is important to choose a drug that effectively eliminates all negative symptoms without having a sedative effect.
One of these medicines is Zodak - it quickly helps to cope with a runny nose, itching and lacrimation, and is suitable for treating patients of all ages. Zodak is a popular remedy for the treatment of runny nose, colds and allergies.

Release form and composition of Zodak

Zodac - listed on the radar as a second generation antihistamine, intended for oral administration, quickly eliminates allergy symptoms, and rarely causes drowsiness.

The main active ingredient is cetirizine; the medicine is produced in various forms, which allows you to choose the optimal remedy for patients of different age categories.

Release forms:

  1. Tablets - with a dosage of the main ingredient of 10 mg, elongated, white, with a separation line on one of the surfaces. The pills are packaged in blisters of 7 or 10 pieces; the package may contain 1, 3, or 7 plates.
  2. Drops are a clear or pale yellow liquid, 1 ml contains 10 mg of the main component. Packaged in dark glass bottles with a volume of 20 ml, the pack also includes a dropper cap.
  3. Syrup is a colorless or light yellow liquid, 5 ml of the drug contains 1 mg of the active substance. There is 100 ml of medicine in a dark glass container; the box also contains instructions and a spoon with divisions.

All forms of the medicine can be purchased at the pharmacy without a prescription; the drug must be stored at a temperature of 10–25 degrees for 36 months. After opening, the drops and syrup can be stored for 14 days, after which the product is considered unsuitable for treatment and must be disposed of.

To purchase an original antiallergic drug, you can first look at its appearance in the photo.

Packaging of Zodak tablets

Packaging of Zodak tablets

Zodak in the form of drops

Zodak in the form of syrup

Price and analogues of the drug

The cost of Zodak is 150–270 rubles, depending on the form of the drug. In pharmacies there are many analogues of the drug that have a similar composition or identical therapeutic effect.

Name of medicinePrice, rub.)
Zodak Express300–550
Fenistil230–330
Tsetrin160–230
Zyrtec220–320
Claritin230–580

Indications Zodak

The drug has a pronounced antiallergic effect and helps to quickly eliminate the main manifestations of the disease.

What does the drug help with:

  • ordinary and chronic idiopathic urticaria;
  • seasonal or chronic allergic rhinitis;
  • acute bacterial, viral, allergic conjunctivitis;
  • with a cough that occurs against the background of spasms and swelling of the bronchi and trachea of ​​various origins;
  • ARVI - the medicine prevents the appearance of signs of intoxication against the background of poisoning of the body with toxic waste products of pathogenic microorganisms, eliminates swelling of the throat and nose;
  • urticaria, psoriasis, scabies and other dermatological pathologies that are accompanied by severe itching;
  • hay fever;
  • Quincke's edema;
  • severe itching with chickenpox;
  • insect bites;
  • any type of diathesis.

Zodak helps get rid of itching due to chickenpox

Zodak is included in complex therapy for the treatment of bronchitis and bronchial asthma, atopic dermatitis, and eczema. Many doctors recommend giving medicine before vaccination to avoid fever and swelling after the vaccine is administered.

pharmachologic effect

Zodak blocks the functioning of histamine receptors, due to which the main manifestations of allergies disappear - swelling, itching, rash, cough, runny nose, lacrimation.

Action of the drug:

  • prevents the occurrence of allergic reactions after vaccination in children;
  • quickly eliminates itching due to viral, bacterial, fungal infections;
  • eliminates itching, burning, nasal congestion, increased lacrimation;
  • works effectively at any stage of allergy development;
  • increases the density of vascular walls, making it more difficult for allergens to penetrate the body;
  • eliminates swelling of mucous and soft tissues;
  • prevents the occurrence of acute reactions upon contact with aggressive chemical substances and allergies to cold.

After 48–72 hours, histamine is destroyed, negative reactions completely disappear, and if the irritant does not enter the body again, the person will no longer suffer from allergies.

On average, the drug begins to act within 15–25 minutes; some patients notice a therapeutic effect only an hour after taking the medicine. The duration of action of an antihistamine in any form is 24 hours.

Instructions for use Zodak

According to the instructions, the drug in tablet form is allowed to be used to treat children over 6 years old, in the form of syrup - over 2 years old, in drops - over a year old. The medicine can be taken at any time of the day, regardless of meals, once every 12 or 24 hours.

How to drink Zodak for adults

Adults can take the drug in any form. The tablets must be swallowed whole, not chewed, washed down with a sufficient amount of water, the syrup must be drunk undiluted, and the drops must be diluted in a small amount of liquid.

The medicine should be taken once a day, or the daily dose should be divided into 2 doses, the interval between which should be 12 hours.

Zodak tablets should be taken without biting

Mode of application:

  • pills – 10 mg per day;
  • drops – 20 drops daily;
  • syrup – 2 measuring spoons per day.

The average duration of treatment is 5–7 days, but in chronic forms of pathologies it can last from several months to a year with interruptions.

Important! For people with severe pathologies of the kidneys and liver, and elderly patients, the dosage of the drug should only be calculated by a doctor, taking into account test results and the person’s general well-being.

Rules for taking the drug for children

The official instructions state that Zodak should not be taken by children under one year of age, but most pediatricians consider this drug safe and prescribe it in the form of drops even for newborns.

But in infants, this remedy can provoke apnea, so parents need to constantly monitor the child’s breathing and general condition.

Experienced doctors recommend that children under one year of age instill the required dose of medication into the nose - this will help minimize the development of adverse reactions.

Form of preparationAge and daily dosage
Drops· less than 3 months – 2 drops; · up to 6 months – 3–4 drops; · 6–12 months – 5 drops; · 1–2 years – 5 drops; · 2–6 years – 10 drops; · over 6 years – 20 drops.
Syrup· 2–6 years – 1 measuring spoon; · over 6 years – 2 measuring spoons.
PillsOver 6 years old – 1 tablet

Can pregnant and lactating women take Zodak?

The drug should absolutely not be taken during pregnancy, especially in the first trimester - antihistamines negatively affect the formation and development of the fetus. During lactation, drinking the drug is also contraindicated.

Zodak is not addictive even with long-term use.

Zodak should not be taken during pregnancy

Side effects

If the recommended dosages are followed, Zodak is well tolerated by patients of any age; negative reactions during treatment rarely occur and usually disappear on their own within a few hours.

Possible adverse reactions:

  • increased manifestations of allergies;
  • dyspeptic disorders in the form of diarrhea, abdominal pain, nausea;
  • strong thirst, change in taste perception;
  • problems with urination, severe swelling - occur in patients with kidney pathologies;
  • increased fatigue or excitability, migraine, dizziness, drowsiness or insomnia;
  • reversible visual impairment.

Since Zodak can provoke an attack of dizziness and drowsiness, at the initial stage of treatment it is necessary to refrain from operating machinery, vehicles, or hazardous types of work.

Headache may occur after taking Zodak

Contraindications

Zodak medicine has a small number of restrictions for use, the main of which is individual intolerance to the components of the drug.

List of contraindications:

  • severe pathologies of the kidneys and liver;
  • lactose intolerance – for tablets;
  • porphyria.

You should not take Zodak if you have kidney problems.

During treatment with Zodak, you should not drink alcohol - the active substance of the drug, together with alcohol, has a strong inhibitory effect on the functioning of the central nervous system.

5 ml of syrup contains 0.25 XE, which should be taken into account by diabetics; there is no sugar in the drops.

Overdose

If the instructions for use are not followed, a person experiences severe drowsiness, lethargy, and sudden attacks of severe agitation or anxiety.

Signs of overdose:

  • strong, unquenchable thirst;
  • attack of tachycardia;
  • problems with urination, constipation;
  • fatigue, weakness;
  • migraine.

If dangerous symptoms appear, it is necessary to rinse the stomach with warm water or a weak solution of potassium permanganate, and take adsorbents.

Overdose of the drug can cause constipation

Zodak or Fenistil - which is better for a child?

Since allergies in children are a fairly common phenomenon, parents are often in search of an effective and safe anti-allergy drug. Zodak and Fenistil are often prescribed by pediatricians to children, but these drugs differ significantly from each other.

Comparison of drugs Zodak and Fenistil

CharacteristicZodakFenistil
Active substancecetirizinedimethindene maleate
Which generation does it belong to?IIII
Release formTablets, drops, syrupDrops, capsules, gel for external use
Spectrum of actionWideDoes not help with allergic rhinitis, bronchospasm, eczema, should not be taken with bronchial asthma
Sedative effectWeak sleepinessExtreme drowsiness
From what age can it be used?From 1 yearFrom 6 months
Minimum duration of therapy5–7 days3–5 days
How long does the medicine last?24 hours5–8 hours
Is it addictive?AbsentSlowly develops with long-term use

Each drug works better in eliminating certain signs of allergy, so when choosing a drug, it is necessary to take into account the type of disease, the totality of all symptoms, contraindications, adverse reactions, and the age of the child.

Which is better: Zodak or Zodak Express?

Despite the similarity in name, these drugs have many differences. The basis of Zodak Express is levocetirizine - this substance has a more pronounced antihistamine effect, so the medicine is considered more effective for treating severe or chronic allergy attacks.

Zodak Express is produced only in tablet form, so it can only be used to treat adults and children over 6 years of age.

Zodak Express is effective in treating allergies

Reviews

Kvakysha

“I like Zodak - I drink it every spring for seasonal runny nose, I give it to my son before and after vaccinations. The medicine is inexpensive, lasts for a day, there were no adverse reactions.”

Nasten_ka

“But Zodak didn’t help me at all - after using the new mascara I developed a terrible allergy, the pharmacy recommended this medicine. An hour later, the condition worsened greatly, my whole face became swollen, it became difficult to breathe, I had to urgently go to the hospital.”

Veterok

“For its price, Zodak is a good drug, but it still causes slight drowsiness and lethargy. I like Telfast better, it costs a little more, but after taking it you won’t be afraid to drive.”

Zodak is a modern and effective remedy for eliminating the main manifestations of allergies; the drug has a fast and long-lasting effect. The medicine has practically no contraindications; if the instructions are followed, adverse reactions rarely occur.

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Source: https://MedBoli.ru/zabolevaniya/lekarstva-zabolevaniya/instruktsiya-po-primeneniyu-zodak-dlya-detej-i-vzroslyh

Side effects of drugs Zodak and Zodak Express

Medicines have side effects such as:

  1. Central nervous system – headache with dizziness, drowsiness, paresthesia, convulsive syndrome, agitation with attacks of aggression, migraine attacks, confusion with hallucinations.
  2. Organs of the gastrointestinal tract - pain in the abdomen, dryness of the oral mucosa, nausea with vomiting, dyspeptic syndrome, inflammation of the liver, perverted taste sensations, anorexia, increased salivation.
  3. Respiratory system - pharyngitis, rhinitis, nosebleeds, shortness of breath.
  4. Skin – in rare cases, rash, urticaria, and dermatitis are possible.
  5. Cardiovascular system - attacks of tachycardia, increased blood pressure, signs of heart failure.
  6. Organs of the genitourinary system - urinary incontinence or retention, urine mixed with blood, bleeding from the uterus.

Zodak is used to eliminate symptoms of rhinitis of allergic origin, dermatitis of atopic nature, and inflammation of the bronchi.

Compare Zodak and Zodak Drops

The results of clinical studies have demonstrated that the use of cetirizine in recommended doses leads to the development of minor adverse effects from the central nervous system, including drowsiness, fatigue, dizziness and headache. In some cases, paradoxical stimulation of the central nervous system has been reported.

In addition to the adverse events identified during clinical trials and described above, the following adverse reactions were observed during post-registration use of the drug. From the hematopoietic system: very rarely - thrombocytopenia. From the immune system: rarely - hypersensitivity reactions; very rarely - anaphylactic shock.

Mental disorders: infrequently – agitation; rarely - aggression, confusion, depression, hallucinations, sleep disturbance; very rarely – tic; frequency unknown - suicidal ideation, sleep disturbances (including nightmares).

From the nervous system: infrequently – paresthesia; rarely – convulsions; very rarely - taste perversion, dyskinesia, dystonia, fainting, tremor; frequency unknown – memory impairment, incl. amnesia. From the organ of vision: very rarely - disturbance of accommodation, blurred vision, nystagmus. On the part of the hearing organ: frequency unknown – vertigo, deafness.

From the cardiovascular system: rarely – tachycardia; frequency unknown – vasculitis. From the digestive system: infrequently – diarrhea; rarely - liver failure with changes in liver function tests (increased activity of transaminases, alkaline phosphatase, GGT and bilirubin); frequency unknown – increased appetite.

From the skin and subcutaneous tissues: infrequently – rash, itching; rarely - urticaria; very rarely - angioedema, persistent drug erythema. From the urinary system: very rarely - dysuria, enuresis; frequency unknown - urinary retention. From the musculoskeletal system: frequency unknown - arthralgia.

General disorders: infrequently – asthenia, malaise; rarely – peripheral edema, weight gain. Description of selected adverse reactions After stopping the use of cetirizine, cases of itching (including intense itching) and/or urticaria were reported. A complete list of side effects and warnings is on the official website https://allergia.pro/product/zodak-tabletki/.

The results of clinical studies have demonstrated that the use of cetirizine in recommended doses leads to the development of minor adverse effects from the central nervous system, including drowsiness, fatigue, dizziness and headache. In some cases, paradoxical stimulation of the central nervous system has been reported.

Despite the fact that cetirizine is a selective blocker of peripheral H1 receptors and has virtually no anticholinergic effect, isolated cases of difficulty urinating, disturbances of accommodation and dry mouth have been reported.

Liver dysfunction has been reported, accompanied by increased activity of liver enzymes and bilirubin. In most cases, adverse events resolved after discontinuation of cetirizine dihydrochloride.

Data are available from double-blind, controlled clinical trials comparing cetirizine with placebo or other antihistamines given at recommended doses (10 mg once daily for cetirizine) in more than 3,200 patients on which a reliable analysis can be made safety data - see instructions in the package. In addition to the adverse events identified during clinical trials and described above, the following adverse reactions were observed during post-registration use of the drug. Based on data from post-marketing use of the drug, adverse events are divided into MedDRA organ system classes and incidence. The incidence of adverse events was determined as follows: very often (>1/10), often (>1/100, 1/1000, 1/10,000,

Interaction with other drugs

Based on the analysis of pharmacodynamics and pharmacokinetics of cetirizine, interaction with other drugs is unlikely.

There was no significant interaction observed with pseudoephedrine and theophylline (at a dose of 400 mg/day) in specific drug interaction studies.

The simultaneous use of cetirizine with ethanol and drugs that depress the central nervous system may further reduce concentration and reaction speed, although cetirizine does not enhance the effect of ethanol (at a blood concentration of 0.5 g/l).

No clinically significant interactions of cetirizine with other drugs have been established.

Based on the results of drug interaction studies of cetirizine, in particular, interaction studies with pseudoephedrine or theophylline at a dose of 400 mg/day, no clinically significant interaction has been established.

The simultaneous use of cetirizine with ethanol and drugs that depress the central nervous system may further reduce concentration and reaction speed, although cetirizine does not enhance the effect of ethanol (at a blood concentration of 0.5 g/l).

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life – 3 years. Do not use after the expiration date stated on the package.

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life – 3 years. Do not use after the expiration date stated on the packaging.

Source: https://sravnimed.ru/zodak-vs-zodak-kapli.html

Reviews from doctors

Miklashevich Vitaly Petrovich, therapist, Smolensk

I often prescribe this medicine for various manifestations of allergic reactions. The drug is instant action, the first effect occurs within 10 minutes. Convenient forms of use: children – syrup, adults – tablets. Affordable price of this medicine, high quality manufacturing. Medicines should be used after consultation with a doctor; there are a number of contraindications for use and side effects.

Artukhevich Zoya Olegovna, allergist, Moscow

These antihistamines do not have sedative properties. I consider them effective in combating allergic manifestations. The medication is available in drops for children and is approved for use from one year onwards. I recommend taking medications only after consulting a doctor.

Patient reviews

Svetlana Petrovna, 50 years old, Samara

I have been suffering from hay fever for many years, only these drugs save me. Quite convenient use - only 1 time per day, regardless of meals. The drug is affordable and can be purchased without a doctor's prescription. No side effects were observed during the entire period of taking the drug.

Victoria, 37 years old, Voronezh

When a child has a food allergy, I give this medicine in the form of a syrup. The drug is effective, acts immediately, and can be used once a day. It is well tolerated by the body, no side effects were observed. For adults there are tablets that are also used once a day.

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